1ya0
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1ya0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YA0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1YA0 FirstGlance]. <br> | <table><tr><td colspan='2'>[[1ya0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YA0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1YA0 FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ya0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ya0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ya0 RCSB], [http://www.ebi.ac.uk/pdbsum/1ya0 PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ya0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ya0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ya0 RCSB], [http://www.ebi.ac.uk/pdbsum/1ya0 PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/SMG7_HUMAN SMG7_HUMAN]] Plays a role in nonsense-mediated mRNA decay. Recruits UPF1 to cytoplasmic mRNA decay bodies. Together with SMG5 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation.<ref>PMID:15546618</ref> <ref>PMID:15721257</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Conti, E | + | [[Category: Conti, E]] |
| - | [[Category: Ebert, J | + | [[Category: Ebert, J]] |
| - | [[Category: Fukuhara, N | + | [[Category: Fukuhara, N]] |
| - | [[Category: Izaurralde, E | + | [[Category: Izaurralde, E]] |
| - | [[Category: Lindner, D | + | [[Category: Lindner, D]] |
| - | [[Category: Unterholzner, L | + | [[Category: Unterholzner, L]] |
[[Category: 14-3-3]] | [[Category: 14-3-3]] | ||
[[Category: Alpha-helical repeat]] | [[Category: Alpha-helical repeat]] | ||
[[Category: Signaling protein]] | [[Category: Signaling protein]] | ||
Revision as of 12:53, 25 December 2014
Crystal structure of the N-terminal domain of human SMG7
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