This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
4ifh
From Proteopedia
(Difference between revisions)
| Line 8: | Line 8: | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ifh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ifh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ifh RCSB], [http://www.ebi.ac.uk/pdbsum/4ifh PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ifh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ifh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ifh RCSB], [http://www.ebi.ac.uk/pdbsum/4ifh PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/IDE_HUMAN IDE_HUMAN]] Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia.<ref>PMID:10684867</ref> <ref>PMID:17613531</ref> <ref>PMID:18986166</ref> | ||
==See Also== | ==See Also== | ||
*[[Insulin-Degrading Enzyme|Insulin-Degrading Enzyme]] | *[[Insulin-Degrading Enzyme|Insulin-Degrading Enzyme]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Revision as of 13:05, 25 December 2014
Crystal structure of human insulin degrading enzyme (IDE) in complex with compound BDM44619
| |||||||||||
