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1q1m
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1q1m]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q1M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Q1M FirstGlance]. <br> | <table><tr><td colspan='2'>[[1q1m]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q1M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Q1M FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=234:5-{2-FLUORO-5-[3-(3-HYDROXY-2-METHOXYCARBONYL-PHENOXY)-PROPENYL]-PHENYL}-ISOXAZOLE-3-CARBOXYLIC+ACID'>234</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=234:5-{2-FLUORO-5-[3-(3-HYDROXY-2-METHOXYCARBONYL-PHENOXY)-PROPENYL]-PHENYL}-ISOXAZOLE-3-CARBOXYLIC+ACID'>234</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1nl9|1nl9]], [[1nny|1nny]], [[1no6|1no6]], [[1nz7|1nz7]], [[1ony|1ony]], [[1pho|1pho]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1nl9|1nl9]], [[1nny|1nny]], [[1no6|1no6]], [[1nz7|1nz7]], [[1ony|1ony]], [[1pho|1pho]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PTPN1 OR PTP1B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PTPN1 OR PTP1B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> |
| - | <tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr> | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1q1m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q1m OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1q1m RCSB], [http://www.ebi.ac.uk/pdbsum/1q1m PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1q1m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q1m OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1q1m RCSB], [http://www.ebi.ac.uk/pdbsum/1q1m PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/PTN1_HUMAN PTN1_HUMAN]] Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion.<ref>PMID:21135139</ref> <ref>PMID:22169477</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Protein-tyrosine-phosphatase]] | [[Category: Protein-tyrosine-phosphatase]] | ||
| - | [[Category: Abad-Zapatero, C | + | [[Category: Abad-Zapatero, C]] |
| - | [[Category: Ballaron, S J | + | [[Category: Ballaron, S J]] |
| - | [[Category: Haasch, D L | + | [[Category: Haasch, D L]] |
| - | [[Category: Hajduk, P J | + | [[Category: Hajduk, P J]] |
| - | [[Category: Hutchins, C W | + | [[Category: Hutchins, C W]] |
| - | [[Category: Jirousek, M R | + | [[Category: Jirousek, M R]] |
| - | [[Category: Kaszubska, W | + | [[Category: Kaszubska, W]] |
| - | [[Category: Liu, G | + | [[Category: Liu, G]] |
| - | [[Category: Lubben, T H | + | [[Category: Lubben, T H]] |
| - | [[Category: Pei, Z | + | [[Category: Pei, Z]] |
| - | [[Category: Rondinone, C M | + | [[Category: Rondinone, C M]] |
| - | [[Category: Trevillyan, J M | + | [[Category: Trevillyan, J M]] |
| - | [[Category: Xin, Z | + | [[Category: Xin, Z]] |
| - | [[Category: Zhao, H | + | [[Category: Zhao, H]] |
[[Category: Hydrolase]] | [[Category: Hydrolase]] | ||
[[Category: Inhibitors with isoxazole-salicylate pharmacophore]] | [[Category: Inhibitors with isoxazole-salicylate pharmacophore]] | ||
[[Category: Protein tyrosine phosphatase 1b]] | [[Category: Protein tyrosine phosphatase 1b]] | ||
[[Category: Ptp1b]] | [[Category: Ptp1b]] | ||
Revision as of 13:33, 25 December 2014
A Highly Efficient Approach to a Selective and Cell Active PTP1B inhibitors
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Categories: Homo sapiens | Protein-tyrosine-phosphatase | Abad-Zapatero, C | Ballaron, S J | Haasch, D L | Hajduk, P J | Hutchins, C W | Jirousek, M R | Kaszubska, W | Liu, G | Lubben, T H | Pei, Z | Rondinone, C M | Trevillyan, J M | Xin, Z | Zhao, H | Hydrolase | Inhibitors with isoxazole-salicylate pharmacophore | Protein tyrosine phosphatase 1b | Ptp1b
