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2q05
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2q05]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Vaccinia_virus_wr Vaccinia virus wr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q05 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Q05 FirstGlance]. <br> | <table><tr><td colspan='2'>[[2q05]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Vaccinia_virus_wr Vaccinia virus wr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q05 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Q05 FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | + | </td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">H1L, VACWR099 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10254 Vaccinia virus WR])</td></tr> | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">H1L, VACWR099 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10254 Vaccinia virus WR])</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2q05 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2q05 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2q05 RCSB], [http://www.ebi.ac.uk/pdbsum/2q05 PDBsum], [http://www.topsan.org/Proteins/MCSG/2q05 TOPSAN]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2q05 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2q05 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2q05 RCSB], [http://www.ebi.ac.uk/pdbsum/2q05 PDBsum], [http://www.topsan.org/Proteins/MCSG/2q05 TOPSAN]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/DUSP_VACCV DUSP_VACCV]] Serine/Tyrosine phosphatase which down-regulates cellular antiviral response by dephosphorylating activated host STAT1 and blocking interferon (IFN)-stimulated innate immune responses. Dephosphorylates the A17 protein.<ref>PMID:1848923</ref> <ref>PMID:10438817</ref> <ref>PMID:11238845</ref> <ref>PMID:18593332</ref> <ref>PMID:21362620</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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==See Also== | ==See Also== | ||
*[[MAP kinase phosphatase|MAP kinase phosphatase]] | *[[MAP kinase phosphatase|MAP kinase phosphatase]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Vaccinia virus wr]] | [[Category: Vaccinia virus wr]] | ||
| - | [[Category: Edwards, A | + | [[Category: Edwards, A]] |
| - | [[Category: Joachimiak, A | + | [[Category: Joachimiak, A]] |
| - | [[Category: Kagan, O | + | [[Category: Kagan, O]] |
| - | [[Category: | + | [[Category: Structural genomic]] |
| - | [[Category: Osipiuk, J | + | [[Category: Osipiuk, J]] |
| - | [[Category: Savchenko, A | + | [[Category: Savchenko, A]] |
| - | [[Category: Skarina, T | + | [[Category: Skarina, T]] |
[[Category: Apc7320]] | [[Category: Apc7320]] | ||
[[Category: Hydrolase]] | [[Category: Hydrolase]] | ||
[[Category: Mcsg]] | [[Category: Mcsg]] | ||
| - | [[Category: Midwest center for structural genomic]] | ||
[[Category: Phosphatase]] | [[Category: Phosphatase]] | ||
| - | [[Category: Protein structure initiative | + | [[Category: PSI, Protein structure initiative]] |
| - | + | ||
| - | + | ||
[[Category: Vaccinia virus]] | [[Category: Vaccinia virus]] | ||
Revision as of 14:26, 25 December 2014
Crystal structure of tyr/ser protein phosphatase from Vaccinia virus WR
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