2vci
From Proteopedia
(Difference between revisions)
| Line 3: | Line 3: | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2vci]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VCI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VCI FirstGlance]. <br> | <table><tr><td colspan='2'>[[2vci]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VCI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VCI FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2GJ:5-[2,4-DIHYDROXY-5-(1-METHYLETHYL)PHENYL]-N-ETHYL-4-[4-(MORPHOLIN-4-YLMETHYL)PHENYL]ISOXAZOLE-3-CARBOXAMIDE'>2GJ</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2GJ:5-[2,4-DIHYDROXY-5-(1-METHYLETHYL)PHENYL]-N-ETHYL-4-[4-(MORPHOLIN-4-YLMETHYL)PHENYL]ISOXAZOLE-3-CARBOXAMIDE'>2GJ</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1osf|1osf]], [[1uy8|1uy8]], [[1uy9|1uy9]], [[1uyd|1uyd]], [[1uye|1uye]], [[1uyh|1uyh]], [[1uyi|1uyi]], [[1uyl|1uyl]], [[1yc4|1yc4]], [[2bt0|2bt0]], [[2bug|2bug]], [[2byh|2byh]], [[2bz5|2bz5]], [[2c2l|2c2l]], [[2ccs|2ccs]], [[2cct|2cct]], [[2ccu|2ccu]], [[2cdd|2cdd]], [[2uwd|2uwd]], [[1byq|1byq]], [[1uy6|1uy6]], [[1uy7|1uy7]], [[1uyc|1uyc]], [[1uyf|1uyf]], [[1uyg|1uyg]], [[1uyk|1uyk]], [[1yc1|1yc1]], [[1yc3|1yc3]], [[2bsm|2bsm]], [[2byi|2byi]], [[2vcj|2vcj]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1osf|1osf]], [[1uy8|1uy8]], [[1uy9|1uy9]], [[1uyd|1uyd]], [[1uye|1uye]], [[1uyh|1uyh]], [[1uyi|1uyi]], [[1uyl|1uyl]], [[1yc4|1yc4]], [[2bt0|2bt0]], [[2bug|2bug]], [[2byh|2byh]], [[2bz5|2bz5]], [[2c2l|2c2l]], [[2ccs|2ccs]], [[2cct|2cct]], [[2ccu|2ccu]], [[2cdd|2cdd]], [[2uwd|2uwd]], [[1byq|1byq]], [[1uy6|1uy6]], [[1uy7|1uy7]], [[1uyc|1uyc]], [[1uyf|1uyf]], [[1uyg|1uyg]], [[1uyk|1uyk]], [[1yc1|1yc1]], [[1yc3|1yc3]], [[2bsm|2bsm]], [[2byi|2byi]], [[2vcj|2vcj]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vci FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vci OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vci RCSB], [http://www.ebi.ac.uk/pdbsum/2vci PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vci FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vci OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vci RCSB], [http://www.ebi.ac.uk/pdbsum/2vci PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN]] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
| Line 33: | Line 35: | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Aherne, W | + | [[Category: Aherne, W]] |
| - | [[Category: Barril, X | + | [[Category: Barril, X]] |
| - | [[Category: Borgognoni, J | + | [[Category: Borgognoni, J]] |
| - | [[Category: Boxal, K | + | [[Category: Boxal, K]] |
| - | [[Category: Brough, P A | + | [[Category: Brough, P A]] |
| - | [[Category: Cansfield, J E | + | [[Category: Cansfield, J E]] |
| - | [[Category: Cheung, K M | + | [[Category: Cheung, K M]] |
| - | [[Category: Collins, I | + | [[Category: Collins, I]] |
| - | [[Category: Davies, N G.M | + | [[Category: Davies, N G.M]] |
| - | [[Category: Drysdale, M J | + | [[Category: Drysdale, M J]] |
| - | [[Category: Dymock, B | + | [[Category: Dymock, B]] |
| - | [[Category: Eccles, S A | + | [[Category: Eccles, S A]] |
| - | [[Category: Finch, H | + | [[Category: Finch, H]] |
| - | [[Category: Fink, A | + | [[Category: Fink, A]] |
| - | [[Category: Hayes, A | + | [[Category: Hayes, A]] |
| - | [[Category: Howes, R | + | [[Category: Howes, R]] |
| - | [[Category: Hubbard, R E | + | [[Category: Hubbard, R E]] |
| - | [[Category: James, K | + | [[Category: James, K]] |
| - | [[Category: Jordan, A M | + | [[Category: Jordan, A M]] |
| - | [[Category: Lockie, A | + | [[Category: Lockie, A]] |
| - | [[Category: Martins, V | + | [[Category: Martins, V]] |
| - | [[Category: Massey, A | + | [[Category: Massey, A]] |
| - | [[Category: Matthews, T P | + | [[Category: Matthews, T P]] |
| - | [[Category: Mcdonald, E | + | [[Category: Mcdonald, E]] |
| - | [[Category: Northfield, C J | + | [[Category: Northfield, C J]] |
| - | [[Category: Pearl, L H | + | [[Category: Pearl, L H]] |
| - | [[Category: Prodromou, C | + | [[Category: Prodromou, C]] |
| - | [[Category: Ray, S | + | [[Category: Ray, S]] |
| - | [[Category: Raynaud, F I | + | [[Category: Raynaud, F I]] |
| - | [[Category: Roughley, S D | + | [[Category: Roughley, S D]] |
| - | [[Category: Sharp, S Y | + | [[Category: Sharp, S Y]] |
| - | [[Category: Surgenor, A | + | [[Category: Surgenor, A]] |
| - | [[Category: Walmsley, D L | + | [[Category: Walmsley, D L]] |
| - | [[Category: Webb, P | + | [[Category: Webb, P]] |
| - | [[Category: Wood, M | + | [[Category: Wood, M]] |
| - | [[Category: Workman, P | + | [[Category: Workman, P]] |
| - | [[Category: Wright, L | + | [[Category: Wright, L]] |
[[Category: Atp-binding]] | [[Category: Atp-binding]] | ||
[[Category: Chaperone]] | [[Category: Chaperone]] | ||
Revision as of 14:36, 25 December 2014
4,5 DIARYL ISOXAZOLE HSP90 CHAPERONE INHIBITORS: POTENTIAL THERAPEUTIC AGENTS FOR THE TREATMENT OF CANCER
| |||||||||||
Categories: Homo sapiens | Aherne, W | Barril, X | Borgognoni, J | Boxal, K | Brough, P A | Cansfield, J E | Cheung, K M | Collins, I | Davies, N G.M | Drysdale, M J | Dymock, B | Eccles, S A | Finch, H | Fink, A | Hayes, A | Howes, R | Hubbard, R E | James, K | Jordan, A M | Lockie, A | Martins, V | Massey, A | Matthews, T P | Mcdonald, E | Northfield, C J | Pearl, L H | Prodromou, C | Ray, S | Raynaud, F I | Roughley, S D | Sharp, S Y | Surgenor, A | Walmsley, D L | Webb, P | Wood, M | Workman, P | Wright, L | Atp-binding | Chaperone | Nucleotide-binding | Phosphorylation | Stress response
