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3c58
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3c58 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3c58 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3c58 RCSB], [http://www.ebi.ac.uk/pdbsum/3c58 PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3c58 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3c58 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3c58 RCSB], [http://www.ebi.ac.uk/pdbsum/3c58 PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/A2RI84_LACLM A2RI84_LACLM]] Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity).[HAMAP-Rule:MF_00103][SAAS:SAAS015886_004_120556] | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Lactococcus lactis]] | [[Category: Lactococcus lactis]] | ||
| - | [[Category: Carell, T | + | [[Category: Carell, T]] |
| - | [[Category: Castaing, B | + | [[Category: Castaing, B]] |
| - | [[Category: Coste, F | + | [[Category: Coste, F]] |
[[Category: Benzyl-fapy]] | [[Category: Benzyl-fapy]] | ||
[[Category: Dna damage]] | [[Category: Dna damage]] | ||
Revision as of 14:46, 25 December 2014
Crystal structure of a complex between the wild-type lactococcus lactis Fpg (MutM) and a N7-Benzyl-Fapy-dG containing DNA
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