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1mm5
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1mm5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MM5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1MM5 FirstGlance]. <br> | <table><tr><td colspan='2'>[[1mm5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MM5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1MM5 FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1mm4|1mm4]]</td></tr> | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1mm4|1mm4]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CrcA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])</td></tr> | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CrcA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mm5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mm5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1mm5 RCSB], [http://www.ebi.ac.uk/pdbsum/1mm5 PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mm5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mm5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1mm5 RCSB], [http://www.ebi.ac.uk/pdbsum/1mm5 PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/CRCA_ECOLI CRCA_ECOLI]] PagP is required both for biosynthesis of hepta-acylated lipid A species containing palmitate and for resistance to cationic antimicrobial peptides (CAMPs). It catalyzes the transfer of a palmitate chain (16:0) from the sn-1 position of a glycerophospholipid to the free hydroxyl group of the (R)-3-hydroxymyristate chain at position 2 of lipid A (endotoxin). Modifications of lipid A with a palmitate chain allow to evade host immune defenses by resisting antimicrobial peptides and attenuating the inflammatory response to infection triggered by lipopolysaccharide through the Toll-like receptor 4 (TLR4) signal transduction pathway. Phosphatidylglycerol (PtdGro), phosphatidylethanolamine (PtdEtn), phosphatidylserine (PtdSer) and phosphatidic acid (Ptd-OH) are all effective acyl donors.<ref>PMID:11013210</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Escherichia coli]] | [[Category: Escherichia coli]] | ||
| - | [[Category: Bishop, R E | + | [[Category: Bishop, R E]] |
| - | [[Category: Chen, L | + | [[Category: Chen, L]] |
| - | [[Category: Choy, W Y | + | [[Category: Choy, W Y]] |
| - | [[Category: Forman-Kay, J D | + | [[Category: Forman-Kay, J D]] |
| - | [[Category: Hwang, P M | + | [[Category: Hwang, P M]] |
| - | [[Category: Kay, L E | + | [[Category: Kay, L E]] |
| - | [[Category: Lo, E I | + | [[Category: Lo, E I]] |
| - | [[Category: Prive, G G | + | [[Category: Prive, G G]] |
| - | [[Category: Raetz, C R.H | + | [[Category: Raetz, C R.H]] |
[[Category: Eta barrel]] | [[Category: Eta barrel]] | ||
[[Category: Palmitoyltransferase]] | [[Category: Palmitoyltransferase]] | ||
[[Category: Transferase]] | [[Category: Transferase]] | ||
Revision as of 14:48, 25 December 2014
Solution NMR structure of the outer membrane enzyme PagP in OG micelles
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