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1j2j
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1j2j]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J2J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1J2J FirstGlance]. <br> | <table><tr><td colspan='2'>[[1j2j]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J2J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1J2J FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1j2h|1j2h]], [[1j2i|1j2i]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1j2h|1j2h]], [[1j2i|1j2i]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1j2j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1j2j OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1j2j RCSB], [http://www.ebi.ac.uk/pdbsum/1j2j PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1j2j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1j2j OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1j2j RCSB], [http://www.ebi.ac.uk/pdbsum/1j2j PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/ARF2_MOUSE ARF2_MOUSE]] GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus. [[http://www.uniprot.org/uniprot/GGA1_HUMAN GGA1_HUMAN]] Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (AC-LL) motif.<ref>PMID:11301005</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
| - | [[Category: Igarashi, N | + | [[Category: Igarashi, N]] |
| - | [[Category: Kato, R | + | [[Category: Kato, R]] |
| - | [[Category: Kawasaki, M | + | [[Category: Kawasaki, M]] |
| - | [[Category: Matsugaki, N | + | [[Category: Matsugaki, N]] |
| - | [[Category: Nakayama, K | + | [[Category: Nakayama, K]] |
| - | [[Category: Nogi, T | + | [[Category: Nogi, T]] |
| - | [[Category: Shiba, T | + | [[Category: Shiba, T]] |
| - | [[Category: Suzuki, M | + | [[Category: Suzuki, M]] |
| - | [[Category: Takatsu, H | + | [[Category: Takatsu, H]] |
| - | [[Category: Wakatsuki, S | + | [[Category: Wakatsuki, S]] |
[[Category: Protein transport]] | [[Category: Protein transport]] | ||
Revision as of 15:32, 25 December 2014
Crystal structure of GGA1 GAT N-terminal region in complex with ARF1 GTP form
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Categories: Homo sapiens | Mus musculus | Igarashi, N | Kato, R | Kawasaki, M | Matsugaki, N | Nakayama, K | Nogi, T | Shiba, T | Suzuki, M | Takatsu, H | Wakatsuki, S | Protein transport
