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1t67
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1t67]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T67 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1T67 FirstGlance]. <br> | <table><tr><td colspan='2'>[[1t67]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T67 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1T67 FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=B3N:4-(DIMETHYLAMINO)-N-[7-(HYDROXYAMINO)-7-OXOHEPTYL]BENZAMIDE'>B3N</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=B3N:4-(DIMETHYLAMINO)-N-[7-(HYDROXYAMINO)-7-OXOHEPTYL]BENZAMIDE'>B3N</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1t64|1t64]], [[1t69|1t69]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1t64|1t64]], [[1t69|1t69]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1t67 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t67 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1t67 RCSB], [http://www.ebi.ac.uk/pdbsum/1t67 PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1t67 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t67 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1t67 RCSB], [http://www.ebi.ac.uk/pdbsum/1t67 PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/HDAC8_HUMAN HDAC8_HUMAN]] Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. May play a role in smooth muscle cell contractility.<ref>PMID:10748112</ref> <ref>PMID:10926844</ref> <ref>PMID:10922473</ref> <ref>PMID:14701748</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Arvai, A | + | [[Category: Arvai, A]] |
| - | [[Category: Buggy, J J | + | [[Category: Buggy, J J]] |
| - | [[Category: Chi, E | + | [[Category: Chi, E]] |
| - | [[Category: Dougan, D R | + | [[Category: Dougan, D R]] |
| - | [[Category: Ho, J D | + | [[Category: Ho, J D]] |
| - | [[Category: Jennings, A J | + | [[Category: Jennings, A J]] |
| - | [[Category: Katz, B A | + | [[Category: Katz, B A]] |
| - | [[Category: Knuth, M W | + | [[Category: Knuth, M W]] |
| - | [[Category: Leahy, E M | + | [[Category: Leahy, E M]] |
| - | [[Category: Luong, C | + | [[Category: Luong, C]] |
| - | [[Category: McRee, D E | + | [[Category: McRee, D E]] |
| - | [[Category: Mol, C | + | [[Category: Mol, C]] |
| - | [[Category: Navre, M | + | [[Category: Navre, M]] |
| - | [[Category: Sang, B C | + | [[Category: Sang, B C]] |
| - | [[Category: Skene, R J | + | [[Category: Skene, R J]] |
| - | [[Category: Snell, G | + | [[Category: Snell, G]] |
| - | [[Category: Somoza, J R | + | [[Category: Somoza, J R]] |
| - | [[Category: Swanson, R V | + | [[Category: Swanson, R V]] |
| - | [[Category: Tang, J | + | [[Category: Tang, J]] |
| - | [[Category: Tari, L W | + | [[Category: Tari, L W]] |
| - | [[Category: Verner, E | + | [[Category: Verner, E]] |
| - | [[Category: Wynands, R | + | [[Category: Wynands, R]] |
[[Category: Histone deacetylase]] | [[Category: Histone deacetylase]] | ||
[[Category: Hydrolase]] | [[Category: Hydrolase]] | ||
[[Category: Zinc hydrolase]] | [[Category: Zinc hydrolase]] | ||
Revision as of 17:06, 25 December 2014
Crystal Structure of Human HDAC8 complexed with MS-344
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Categories: Homo sapiens | Arvai, A | Buggy, J J | Chi, E | Dougan, D R | Ho, J D | Jennings, A J | Katz, B A | Knuth, M W | Leahy, E M | Luong, C | McRee, D E | Mol, C | Navre, M | Sang, B C | Skene, R J | Snell, G | Somoza, J R | Swanson, R V | Tang, J | Tari, L W | Verner, E | Wynands, R | Histone deacetylase | Hydrolase | Zinc hydrolase
