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4fz5
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4fz5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fz5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4fz5 RCSB], [http://www.ebi.ac.uk/pdbsum/4fz5 PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4fz5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fz5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4fz5 RCSB], [http://www.ebi.ac.uk/pdbsum/4fz5 PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/TIRAP_HUMAN TIRAP_HUMAN]] Adapter involved in TLR2 and TLR4 signaling pathways in the innate immune response. Acts via IRAK2 and TRAF-6, leading to the activation of NF-kappa-B, MAPK1, MAPK3 and JNK, and resulting in cytokine secretion and the inflammatory response. Positively regulates the production of TNF-alpha and interleukin-6.<ref>PMID:18292575</ref> <ref>PMID:19509286</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Revision as of 18:29, 25 December 2014
Crystal Structure of Human TIRAP TIR-domain
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Categories: Homo sapiens | Kim, S | Park, S | Shoelson, S E | Woo, J R | Immune system | Myd88 | Scaffold | Tirap
