This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
3o22
From Proteopedia
(Difference between revisions)
| Line 9: | Line 9: | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3o22 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3o22 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3o22 RCSB], [http://www.ebi.ac.uk/pdbsum/3o22 PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3o22 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3o22 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3o22 RCSB], [http://www.ebi.ac.uk/pdbsum/3o22 PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/PTGDS_HUMAN PTGDS_HUMAN]] Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophopic molecules and as a secretory retinoid and thyroid hormone transporter. Possibly involved in development and maintenance of the blood-brain, blood-retina, blood-aqueous humor and blood-testis barrier. It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system.<ref>PMID:9475419</ref> <ref>PMID:20667974</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
| Line 22: | Line 24: | ||
==See Also== | ==See Also== | ||
*[[Prostaglandin D synthase|Prostaglandin D synthase]] | *[[Prostaglandin D synthase|Prostaglandin D synthase]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Revision as of 19:22, 25 December 2014
Structure-function analysis of human L-Prostaglandin D Synthase bound with fatty acid
| |||||||||||
Categories: Homo sapiens | Prostaglandin-D synthase | Li, Y | Liu, Z J | Shaw, N | Zhang, R | Zhao, Y | Zhou, Y | Isomerase | Lipocalin | Prostaglandin synthase
