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2lrs
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lrs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lrs OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2lrs RCSB], [http://www.ebi.ac.uk/pdbsum/2lrs PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lrs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lrs OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2lrs RCSB], [http://www.ebi.ac.uk/pdbsum/2lrs PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/DCL1_ARATH DCL1_ARATH]] Ribonuclease (RNase) III involved in RNA-mediated post-transcriptional gene silencing (PTGS). Functions in the microRNAs (miRNAs) biogenesis pathway by cleaving primary miRNAs (pri-miRNAs) and precursor miRNAs (pre-miRNAs). Functions with DRB1/HYL1 and SERRATE proteins for accurate pri-miRNAs to miRNAs processing. Indirectly involved in the production of trans-acting small interfering RNAs (ta-siRNAs) derived from the TAS1, TAS2 or TAS3 endogenous transcripts by participating in the production of their initiating miRNAs. Involved in the processing of natural siRNAs (nat-siRNAs, derived from cis-natural antisense transcripts) by cleaving 24 nucleotide nat-siRNAs into 21 nucleotide nat-siRNAs. Can produce RDR6-dependent endogenous ta-siRNAs derived from TAS1 and TAS2. Required for the production of 30-40 nucleotide bacterial-induced long siRNAs (lsiRNA). Acts redundantly with DICER-LIKE 3 (DCL3) to promote flowering via repression of FLOWERING LOCUS C (FLC). Represses antiviral RNA silencing through negative regulation of the expression of DCL4 and DCL3.<ref>PMID:15821876</ref> <ref>PMID:16040244</ref> <ref>PMID:16428603</ref> <ref>PMID:17579240</ref> <ref>PMID:18003861</ref> <ref>PMID:18632569</ref> <ref>PMID:18799732</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Arabidopsis thaliana]] | [[Category: Arabidopsis thaliana]] | ||
| - | [[Category: Bersch, B | + | [[Category: Bersch, B]] |
| - | [[Category: Boisbouvier, J | + | [[Category: Boisbouvier, J]] |
| - | [[Category: Bologna, N | + | [[Category: Bologna, N]] |
| - | [[Category: Burdisso, P | + | [[Category: Burdisso, P]] |
| - | [[Category: Palatnik, J | + | [[Category: Palatnik, J]] |
| - | [[Category: Rasia, R | + | [[Category: Rasia, R]] |
| - | [[Category: Suarez, I | + | [[Category: Suarez, I]] |
[[Category: Hydrolase]] | [[Category: Hydrolase]] | ||
[[Category: Mirna]] | [[Category: Mirna]] | ||
[[Category: Rna binding]] | [[Category: Rna binding]] | ||
Revision as of 19:53, 25 December 2014
The second dsRBD domain from A. thaliana DICER-LIKE 1
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Categories: Arabidopsis thaliana | Bersch, B | Boisbouvier, J | Bologna, N | Burdisso, P | Palatnik, J | Rasia, R | Suarez, I | Hydrolase | Mirna | Rna binding
