1vtx
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1vtx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Hadronyche_versuta Hadronyche versuta]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VTX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1VTX FirstGlance]. <br> | <table><tr><td colspan='2'>[[1vtx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Hadronyche_versuta Hadronyche versuta]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VTX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1VTX FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1vtx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vtx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1vtx RCSB], [http://www.ebi.ac.uk/pdbsum/1vtx PDBsum]</span></td></tr> | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1vtx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vtx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1vtx RCSB], [http://www.ebi.ac.uk/pdbsum/1vtx PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/TXDT1_HADVE TXDT1_HADVE]] Inhibits tetrodotoxin-sensitive voltage-gated sodium channels (Nav) by binding to site 3. Slows the inactivation, and causes a prolongation of action potential duration resulting in repetitive firing in autonomic and motor nerve fibers. Does not depolarize the resting potential. Does not affect tetrodotoxin-resistant sodium channels. This lethal neurotoxin is active on both insect and mammalian voltage-gated sodium channels. Pan-neuronal expression in Drosophila is lethal but flies engineered to express the toxin only in pacemaker neurons have profound defects in circadian rhythm but a normal lifespan.<ref>PMID:8281423</ref> <ref>PMID:7816562</ref> <ref>PMID:9028001</ref> <ref>PMID:9845331</ref> <ref>PMID:11171353</ref> <ref>PMID:11874465</ref> <ref>PMID:18986214</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Hadronyche versuta]] | [[Category: Hadronyche versuta]] | ||
| - | [[Category: Chapman, B E | + | [[Category: Chapman, B E]] |
| - | [[Category: Fletcher, J I | + | [[Category: Fletcher, J I]] |
| - | [[Category: King, G F | + | [[Category: King, G F]] |
[[Category: Cysteine knot]] | [[Category: Cysteine knot]] | ||
[[Category: Neurotoxin]] | [[Category: Neurotoxin]] | ||
[[Category: Sodium channel toxin]] | [[Category: Sodium channel toxin]] | ||
[[Category: Venom]] | [[Category: Venom]] | ||
Revision as of 19:55, 25 December 2014
DELTA-ATRACOTOXIN-HV1 (VERSUTOXIN) FROM HADRONYCHE VERSUTA, NMR, 20 STRUCTURES
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