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5eat
From Proteopedia
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[5eat]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/American_tobacco American tobacco]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EAT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5EAT FirstGlance]. <br> | <table><tr><td colspan='2'>[[5eat]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/American_tobacco American tobacco]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EAT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5EAT FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FHP:1-HYDROXY-3,7,11-TRIMETHYLDODECA-2,6,10-TRIENE+PHOSPHONIC+ACID'>FHP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FHP:1-HYDROXY-3,7,11-TRIMETHYLDODECA-2,6,10-TRIENE+PHOSPHONIC+ACID'>FHP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5eat FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5eat OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5eat RCSB], [http://www.ebi.ac.uk/pdbsum/5eat PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5eat FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5eat OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5eat RCSB], [http://www.ebi.ac.uk/pdbsum/5eat PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/5EAS_TOBAC 5EAS_TOBAC]] Catalyzes the cyclization of trans,trans-farnesyl diphosphate (FPP) to the bicyclic intermediate 5-epi-aristolochene, initial step in the conversion of FPP to the sesquiterpenoid antifungal phytoalexin capsidiol. Produces germacrene A as an enzyme-bound intermediate that is not released by the enzyme, but is further cyclized to produce the bicyclic 5-epi-aristolochene. | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: American tobacco]] | [[Category: American tobacco]] | ||
| - | [[Category: Back, K | + | [[Category: Back, K]] |
| - | [[Category: Chappell, J | + | [[Category: Chappell, J]] |
| - | [[Category: Noel, J P | + | [[Category: Noel, J P]] |
| - | [[Category: Starks, C M | + | [[Category: Starks, C M]] |
[[Category: 5-epi-aristolochene synthase]] | [[Category: 5-epi-aristolochene synthase]] | ||
[[Category: Isoprenoid biosynthesis]] | [[Category: Isoprenoid biosynthesis]] | ||
Revision as of 21:14, 25 December 2014
5-EPI-ARISTOLOCHENE SYNTHASE FROM NICOTIANA TABACUM WITH SUBSTRATE ANALOG FARNESYL HYDROXYPHOSPHONATE
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