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1z6i
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1z6i]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z6I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Z6I FirstGlance]. <br> | <table><tr><td colspan='2'>[[1z6i]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z6I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Z6I FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PGRP-LC, ird7, PGRPLC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 Drosophila melanogaster])</td></tr> | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PGRP-LC, ird7, PGRPLC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 Drosophila melanogaster])</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1z6i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z6i OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1z6i RCSB], [http://www.ebi.ac.uk/pdbsum/1z6i PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1z6i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z6i OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1z6i RCSB], [http://www.ebi.ac.uk/pdbsum/1z6i PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/PGPLC_DROME PGPLC_DROME]] Major activator of the imd/Relish pathway and is likely to encode a pattern recognition molecule for the humoral immune response. Required for Relish processing and nuclear translocation following proteolytic cleavage. Involved in the response to lipopolysaccharide (LPS) and peptidoglycan of Gram-negative bacteria. The different isoforms probably display different recognition capabilities to various microbial patterns. Isoform a and isoform x mediate the induction by LPS and Gram-negative bacteria, while isoform x mediates the induction by peptidoglycan.<ref>PMID:11872802</ref> <ref>PMID:12777387</ref> <ref>PMID:16006509</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Drosophila melanogaster]] | [[Category: Drosophila melanogaster]] | ||
| - | [[Category: Chang, C I | + | [[Category: Chang, C I]] |
| - | [[Category: Chelliah, Y | + | [[Category: Chelliah, Y]] |
| - | [[Category: Deisenhofer, J | + | [[Category: Deisenhofer, J]] |
| - | [[Category: Ihara, K | + | [[Category: Ihara, K]] |
| - | [[Category: Mengin-Lecreulx, D | + | [[Category: Mengin-Lecreulx, D]] |
| - | [[Category: Wakatsuki, S | + | [[Category: Wakatsuki, S]] |
[[Category: 3/10 helix]] | [[Category: 3/10 helix]] | ||
[[Category: Immune system]] | [[Category: Immune system]] | ||
[[Category: Membrane protein]] | [[Category: Membrane protein]] | ||
[[Category: Mixed beta-sheet]] | [[Category: Mixed beta-sheet]] | ||
Revision as of 21:54, 25 December 2014
Crystal structure of the ectodomain of Drosophila transmembrane receptor PGRP-LCa
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