Sandbox Reserved 966

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==Structure of the "Clostridium botulinum" neurotoxin serotype A light chain with Zn2+ cofactor bound==
==Structure of the "Clostridium botulinum" neurotoxin serotype A light chain with Zn2+ cofactor bound==
<StructureSection load='3BON' size='340' side='right' caption='Caption for this structure' scene=''>
<StructureSection load='3BON' size='340' side='right' caption='Caption for this structure' scene=''>
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The Clostridium botulinum neurotoxin produced by the bacteria ''Clostridium botulinum'' (and some strains of ''Clostridium butyricium'' and ''Clostridium baratii'') is the most lethal toxin known today. Seven serotypically botulinum neurotoxins (BoNTs) have been found, each of them is categorized into subtypes depending on their amino acid sequence.<ref>PMID: 24975322</ref>
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The Clostridium botulinum neurotoxin produced by the bacteria ''Clostridium botulinum'' (and some strains of ''Clostridium butyricium'' and ''Clostridium baratii'') is the most lethal toxin known today. Seven serotypically botulinum neurotoxins (BoNTs) have been found, each of them is categorized into subtypes depending on their amino acid sequence. The protein is initially synthesized as a single polypeptide chain of ≈150 kDa and is then cleaved by a protease to yield the mature toxin, which consists of a light chain (LC which is 50 kDa) and a heavy chain (HC which is 100 kDa). LC and HC are held together by a long peptide belt, non-covalent interactions and a single inter-chain disulphide bond <ref>PMID: 24975322</ref>
== Function ==
== Function ==

Revision as of 09:07, 30 December 2014

This Sandbox is Reserved from 15/11/2014, through 15/05/2015 for use in the course "Biomolecule" taught by Bruno Kieffer at the Strasbourg University. This reservation includes Sandbox Reserved 951 through Sandbox Reserved 975.
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Structure of the "Clostridium botulinum" neurotoxin serotype A light chain with Zn2+ cofactor bound

Caption for this structure

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References

  1. ↑ Rossetto O, Pirazzini M, Montecucco C. Botulinum neurotoxins: genetic, structural and mechanistic insights. Nat Rev Microbiol. 2014 Aug;12(8):535-49. doi: 10.1038/nrmicro3295. Epub 2014 Jun, 30. PMID:24975322 doi:http://dx.doi.org/10.1038/nrmicro3295
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