2g7c

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[[Image:2g7c.gif|left|200px]]<br /><applet load="2g7c" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:2g7c.gif|left|200px]]
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caption="2g7c, resolution 2.0&Aring;" />
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'''Clostridium difficile Toxin A Fragment Bound to aGal(1,3)bGal(1,4)bGlcNAc'''<br />
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{{Structure
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|PDB= 2g7c |SIZE=350|CAPTION= <scene name='initialview01'>2g7c</scene>, resolution 2.0&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>
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|ACTIVITY=
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|GENE= toxA, tcdA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1496 Clostridium difficile])
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}}
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'''Clostridium difficile Toxin A Fragment Bound to aGal(1,3)bGal(1,4)bGlcNAc'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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2G7C is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Clostridium_difficile Clostridium difficile] with <scene name='pdbligand=GOL:'>GOL</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G7C OCA].
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2G7C is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Clostridium_difficile Clostridium difficile]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G7C OCA].
==Reference==
==Reference==
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Carbohydrate recognition by Clostridium difficile toxin A., Greco A, Ho JG, Lin SJ, Palcic MM, Rupnik M, Ng KK, Nat Struct Mol Biol. 2006 May;13(5):460-1. Epub 2006 Apr 16. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16622409 16622409]
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Carbohydrate recognition by Clostridium difficile toxin A., Greco A, Ho JG, Lin SJ, Palcic MM, Rupnik M, Ng KK, Nat Struct Mol Biol. 2006 May;13(5):460-1. Epub 2006 Apr 16. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16622409 16622409]
[[Category: Clostridium difficile]]
[[Category: Clostridium difficile]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: protein-carbohydrate complex]]
[[Category: protein-carbohydrate complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:28:51 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:01:16 2008''

Revision as of 15:01, 20 March 2008

Image:2g7c.gif


PDB ID 2g7c

Drag the structure with the mouse to rotate
, resolution 2.0Å
Ligands:
Gene: toxA, tcdA (Clostridium difficile)
Coordinates: save as pdb, mmCIF, xml



Clostridium difficile Toxin A Fragment Bound to aGal(1,3)bGal(1,4)bGlcNAc


Overview

Clostridium difficile TcdA is a large toxin that binds carbohydrates on intestinal epithelial cells. A 2-A resolution cocrystal structure reveals two molecules of alpha-Gal-(1,3)-beta-Gal-(1,4)-beta-GlcNAcO(CH(2))(8)CO(2)CH(3) binding in an extended conformation to TcdA. Residues forming key contacts with the trisaccharides are conserved in all seven putative binding sites in TcdA, suggesting a mode of multivalent binding that may be exploited for the rational design of novel therapeutics.

About this Structure

2G7C is a Single protein structure of sequence from Clostridium difficile. Full crystallographic information is available from OCA.

Reference

Carbohydrate recognition by Clostridium difficile toxin A., Greco A, Ho JG, Lin SJ, Palcic MM, Rupnik M, Ng KK, Nat Struct Mol Biol. 2006 May;13(5):460-1. Epub 2006 Apr 16. PMID:16622409

Page seeded by OCA on Thu Mar 20 17:01:16 2008

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