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3v06

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[[Image:3v06.jpg|left|200px]]
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==Crystal structure of S-6'-Me-3'-fluoro hexitol nucleic acid==
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<StructureSection load='3v06' size='340' side='right' caption='[[3v06]], [[Resolution|resolution]] 1.53&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3v06]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V06 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3V06 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SR:STRONTIUM+ION'>SR</scene></td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=F5H:3,7-ANHYDRO-1,5,6-TRIDEOXY-5-FLUORO-6-(5-METHYL-2,4-DIOXO-3,4-DIHYDROPYRIMIDIN-1(2H)-YL)-2-O-PHOSPHONO-D-GLYCERO-L-ALTRO-HEPTITOL'>F5H</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3v07|3v07]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3v06 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v06 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3v06 RCSB], [http://www.ebi.ac.uk/pdbsum/3v06 PDBsum]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Locked nucleic acid (LNA) analogues with 2',4'-bridged sugars show promise in antisense applications. S-5'-Me-LNA has high RNA affinity, and modified oligonucleotides show weakened immune stimulation in vivo. Conversely, an R-5'-methyl group dramatically lowers RNA affinity. To test the effects of S- and R-6'-methyl groups on 3'-fluoro hexitol nucleic acid (FHNA) stability, we synthesized S- and R-6'-Me-FHNA thymidine and incorporated them into oligo-2'-deoxynucleotides. As with LNA, S-6'-Me is stabilizing whereas R-6'-Me is destabilizing. Crystal structures of 6'-Me-FHNA-modified DNAs explain the divergent consequences for stability and suggest convergent origins of these effects by S- and R-6'-Me (FHNA) [-5'-Me (LNA and RNA)] substituents.
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Insights from crystal structures into the opposite effects on RNA affinity caused by the s- and R-6'-methyl backbone modifications of 3'-fluoro hexitol nucleic Acid.,Pallan PS, Yu J, Allerson CR, Swayze EE, Seth P, Egli M Biochemistry. 2012 Jan 10;51(1):7-9. Epub 2011 Dec 29. PMID:22229409<ref>PMID:22229409</ref>
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The line below this paragraph, containing "STRUCTURE_3v06", creates the "Structure Box" on the page.
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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or leave the SCENE parameter empty for the default display.
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{{STRUCTURE_3v06| PDB=3v06 | SCENE= }}
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===Crystal structure of S-6'-Me-3'-fluoro hexitol nucleic acid===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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== References ==
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<!--
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_22229409}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 22229409 is the PubMed ID number.
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</StructureSection>
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[[Category: Egli, M]]
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{{ABSTRACT_PUBMED_22229409}}
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[[Category: Pallan, P S]]
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==About this Structure==
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[[3v06]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V06 OCA].
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==Reference==
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<ref group="xtra">PMID:022229409</ref><references group="xtra"/>
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[[Category: Egli, M.]]
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[[Category: Pallan, P S.]]
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[[Category: 3'-fluoro hexitol nucleic acid]]
[[Category: 3'-fluoro hexitol nucleic acid]]
[[Category: A-form dna]]
[[Category: A-form dna]]

Revision as of 09:53, 4 January 2015

Crystal structure of S-6'-Me-3'-fluoro hexitol nucleic acid

3v06, resolution 1.53Å

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