3udl
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3udl]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Hepatitis_c_virus_subtype_1b Hepatitis c virus subtype 1b]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UDL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3UDL FirstGlance]. <br> | <table><tr><td colspan='2'>[[3udl]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Hepatitis_c_virus_subtype_1b Hepatitis c virus subtype 1b]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UDL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3UDL FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=KLI:3-(5-BENZYL-1,2,4-OXADIAZOL-3-YL)-6-FLUORO-1-[2-FLUORO-4-(TRIFLUOROMETHYL)BENZYL]-7-(4-METHYLPIPERAZIN-1-YL)QUINOLIN-4(1H)-ONE'>KLI</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=KLI:3-(5-BENZYL-1,2,4-OXADIAZOL-3-YL)-6-FLUORO-1-[2-FLUORO-4-(TRIFLUOROMETHYL)BENZYL]-7-(4-METHYLPIPERAZIN-1-YL)QUINOLIN-4(1H)-ONE'>KLI</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3udl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3udl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3udl RCSB], [http://www.ebi.ac.uk/pdbsum/3udl PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3udl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3udl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3udl RCSB], [http://www.ebi.ac.uk/pdbsum/3udl PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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Quinolones as HCV NS5B polymerase inhibitors.,Kumar DV, Rai R, Brameld KA, Somoza JR, Rajagopalan R, Janc JW, Xia YM, Ton TL, Shaghafi MB, Hu H, Lehoux I, To N, Young WB, Green MJ Bioorg Med Chem Lett. 2011 Jan 1;21(1):82-7. Epub 2010 Nov 21. PMID:21145235<ref>PMID:21145235</ref> | Quinolones as HCV NS5B polymerase inhibitors.,Kumar DV, Rai R, Brameld KA, Somoza JR, Rajagopalan R, Janc JW, Xia YM, Ton TL, Shaghafi MB, Hu H, Lehoux I, To N, Young WB, Green MJ Bioorg Med Chem Lett. 2011 Jan 1;21(1):82-7. Epub 2010 Nov 21. PMID:21145235<ref>PMID:21145235</ref> | ||
| - | From | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
</div> | </div> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Hepatitis c virus subtype 1b]] | [[Category: Hepatitis c virus subtype 1b]] | ||
| - | [[Category: Somoza, J R | + | [[Category: Somoza, J R]] |
[[Category: Drug design]] | [[Category: Drug design]] | ||
[[Category: Hcv]] | [[Category: Hcv]] | ||
[[Category: Hydrolase-hydrolase inhibitor complex]] | [[Category: Hydrolase-hydrolase inhibitor complex]] | ||
[[Category: Polymerase]] | [[Category: Polymerase]] | ||
Revision as of 10:54, 4 January 2015
3-heterocyclyl quinolone bound to HCV NS5B
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