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4cod
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4cod]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4COD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4COD FirstGlance]. <br> | <table><tr><td colspan='2'>[[4cod]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4COD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4COD FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=KV1:N-((3R,5S)-1-(BENZOFURAN-3-CARBONYL)-5-(ETHYLCARBAMOYL)PYRROLIDIN-3-YL)-3-ETHYL-1-METHYL-1H-PYRAZOLE-5-CARBOXAMIDE'>KV1</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=KV1:N-((3R,5S)-1-(BENZOFURAN-3-CARBONYL)-5-(ETHYLCARBAMOYL)PYRROLIDIN-3-YL)-3-ETHYL-1-METHYL-1H-PYRAZOLE-5-CARBOXAMIDE'>KV1</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Enoyl-[acyl-carrier-protein]_reductase_(NADH) Enoyl-[acyl-carrier-protein] reductase (NADH)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.1.9 1.3.1.9] </span></td></tr> | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Enoyl-[acyl-carrier-protein]_reductase_(NADH) Enoyl-[acyl-carrier-protein] reductase (NADH)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.1.9 1.3.1.9] </span></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cod FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cod OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4cod RCSB], [http://www.ebi.ac.uk/pdbsum/4cod PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cod FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cod OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4cod RCSB], [http://www.ebi.ac.uk/pdbsum/4cod PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Castro-Pichel, J | + | [[Category: Castro-Pichel, J]] |
| - | [[Category: Convery, M A | + | [[Category: Convery, M A]] |
| - | [[Category: Encinas, L | + | [[Category: Encinas, L]] |
| - | [[Category: Evindar, G | + | [[Category: Evindar, G]] |
| - | [[Category: McDowell, W | + | [[Category: McDowell, W]] |
| - | [[Category: Mendoza-Losana, A | + | [[Category: Mendoza-Losana, A]] |
| - | [[Category: Neu, M | + | [[Category: Neu, M]] |
| - | [[Category: OKeefe, H | + | [[Category: OKeefe, H]] |
| - | [[Category: Pages, L B | + | [[Category: Pages, L B]] |
[[Category: Elt]] | [[Category: Elt]] | ||
[[Category: Encoded library technology]] | [[Category: Encoded library technology]] | ||
Revision as of 14:14, 4 January 2015
Encoded library technology as a source of hits for the discovery and lead optimization of a potent and selective class of bactericidal direct inhibitors of Mycobacterium tuberculosis InhA
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