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2hnk

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[[Image:2hnk.jpg|left|200px]]<br /><applet load="2hnk" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:2hnk.jpg|left|200px]]
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caption="2hnk, resolution 2.300&Aring;" />
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'''Crystal structure of SAM-dependent O-methyltransferase from pathogenic bacterium Leptospira interrogans'''<br />
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{{Structure
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|PDB= 2hnk |SIZE=350|CAPTION= <scene name='initialview01'>2hnk</scene>, resolution 2.300&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene> and <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''Crystal structure of SAM-dependent O-methyltransferase from pathogenic bacterium Leptospira interrogans'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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2HNK is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Leptospira_interrogans Leptospira interrogans] with <scene name='pdbligand=SO4:'>SO4</scene>, <scene name='pdbligand=SAH:'>SAH</scene> and <scene name='pdbligand=PEG:'>PEG</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HNK OCA].
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2HNK is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Leptospira_interrogans Leptospira interrogans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HNK OCA].
==Reference==
==Reference==
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Crystal structure of SAM-dependent O-methyltransferase from pathogenic bacterium Leptospira interrogans., Hou X, Wang Y, Zhou Z, Bao S, Lin Y, Gong W, J Struct Biol. 2007 Sep;159(3):523-8. Epub 2007 Apr 30. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17561415 17561415]
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Crystal structure of SAM-dependent O-methyltransferase from pathogenic bacterium Leptospira interrogans., Hou X, Wang Y, Zhou Z, Bao S, Lin Y, Gong W, J Struct Biol. 2007 Sep;159(3):523-8. Epub 2007 Apr 30. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17561415 17561415]
[[Category: Leptospira interrogans]]
[[Category: Leptospira interrogans]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: transferase]]
[[Category: transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:43:46 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:19:16 2008''

Revision as of 15:19, 20 March 2008

Image:2hnk.jpg


PDB ID 2hnk

Drag the structure with the mouse to rotate
, resolution 2.300Å
Ligands: , and
Coordinates: save as pdb, mmCIF, xml



Crystal structure of SAM-dependent O-methyltransferase from pathogenic bacterium Leptospira interrogans


Overview

The S-adenosylmethionine (SAM)-dependent O-methyltransferase from Leptospira interrogans (LiOMT) expressed by gene LA0415 belongs to the Methyltransf_3 family (Pfam PF01596). In this family all of the five bacterial homologues with known function are reported as SAM-dependent O-methylstransferases involved in antibiotic production. The crystal structure of LiOMT in complex with S-adenosylhomocysteine reported here is the first bacterial protein structure in this family. The LiOMT structure shows a conserved SAM-binding region and a probable metal-dependent catalytic site. The molecules of LiOMT generate homodimers by N-terminal swapping, which assists the pre-organization of the substrate-binding site. Based on the sequence and structural analysis, it is implied by the catalytic and substrate-binding site that the substrate of LiOMT is a phenolic derivative, which probably has a large ring-shaped moiety.

About this Structure

2HNK is a Single protein structure of sequence from Leptospira interrogans. Full crystallographic information is available from OCA.

Reference

Crystal structure of SAM-dependent O-methyltransferase from pathogenic bacterium Leptospira interrogans., Hou X, Wang Y, Zhou Z, Bao S, Lin Y, Gong W, J Struct Biol. 2007 Sep;159(3):523-8. Epub 2007 Apr 30. PMID:17561415

Page seeded by OCA on Thu Mar 20 17:19:16 2008

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