This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
1k7l
From Proteopedia
(Difference between revisions)
| Line 3: | Line 3: | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1k7l]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K7L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1K7L FirstGlance]. <br> | <table><tr><td colspan='2'>[[1k7l]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K7L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1K7L FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=544:2-(1-METHYL-3-OXO-3-PHENYL-PROPYLAMINO)-3-{4-[2-(5-METHYL-2-PHENYL-OXAZOL-4-YL)-ETHOXY]-PHENYL}-PROPIONIC+ACID'>544</scene>, <scene name='pdbligand=YT3:YTTRIUM+(III)+ION'>YT3</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=544:2-(1-METHYL-3-OXO-3-PHENYL-PROPYLAMINO)-3-{4-[2-(5-METHYL-2-PHENYL-OXAZOL-4-YL)-ETHOXY]-PHENYL}-PROPIONIC+ACID'>544</scene>, <scene name='pdbligand=YT3:YTTRIUM+(III)+ION'>YT3</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1k74|1k74]], [[1fm6|1fm6]], [[1fm9|1fm9]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1k74|1k74]], [[1fm6|1fm6]], [[1fm9|1fm9]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1k7l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k7l OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1k7l RCSB], [http://www.ebi.ac.uk/pdbsum/1k7l PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1k7l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k7l OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1k7l RCSB], [http://www.ebi.ac.uk/pdbsum/1k7l PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
== Disease == | == Disease == | ||
[[http://www.uniprot.org/uniprot/NCOA1_HUMAN NCOA1_HUMAN]] Note=A chromosomal aberration involving NCOA1 is a cause of rhabdomyosarcoma. Translocation t(2;2)(q35;p23) with PAX3 generates the NCOA1-PAX3 oncogene consisting of the N-terminus part of PAX3 and the C-terminus part of NCOA1. The fusion protein acts as a transcriptional activator. Rhabdomyosarcoma is the most common soft tissue carcinoma in childhood, representing 5-8% of all malignancies in children. | [[http://www.uniprot.org/uniprot/NCOA1_HUMAN NCOA1_HUMAN]] Note=A chromosomal aberration involving NCOA1 is a cause of rhabdomyosarcoma. Translocation t(2;2)(q35;p23) with PAX3 generates the NCOA1-PAX3 oncogene consisting of the N-terminus part of PAX3 and the C-terminus part of NCOA1. The fusion protein acts as a transcriptional activator. Rhabdomyosarcoma is the most common soft tissue carcinoma in childhood, representing 5-8% of all malignancies in children. | ||
| Line 37: | Line 37: | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Collins, J L | + | [[Category: Collins, J L]] |
| - | [[Category: Gampe, R T | + | [[Category: Gampe, R T]] |
| - | [[Category: Kliewer, S A | + | [[Category: Kliewer, S A]] |
| - | [[Category: Lambert, M H | + | [[Category: Lambert, M H]] |
| - | [[Category: McKee, D D | + | [[Category: McKee, D D]] |
| - | [[Category: Montana, V G | + | [[Category: Montana, V G]] |
| - | [[Category: Moore, J T | + | [[Category: Moore, J T]] |
| - | [[Category: Moore, L B | + | [[Category: Moore, L B]] |
| - | [[Category: Oplinger, J A | + | [[Category: Oplinger, J A]] |
| - | [[Category: Willson, T M | + | [[Category: Willson, T M]] |
| - | [[Category: Xu, H E | + | [[Category: Xu, H E]] |
[[Category: The 2 5 angstrom resolution crystal structure of the human pparalpha ligand binding domain bound with gw409544 and a coactivator peptide]] | [[Category: The 2 5 angstrom resolution crystal structure of the human pparalpha ligand binding domain bound with gw409544 and a coactivator peptide]] | ||
[[Category: Transcription]] | [[Category: Transcription]] | ||
Revision as of 17:01, 5 January 2015
The 2.5 Angstrom resolution crystal structure of the human PPARalpha ligand binding domain bound with GW409544 and a co-activator peptide.
| |||||||||||
Categories: Homo sapiens | Collins, J L | Gampe, R T | Kliewer, S A | Lambert, M H | McKee, D D | Montana, V G | Moore, J T | Moore, L B | Oplinger, J A | Willson, T M | Xu, H E | The 2 5 angstrom resolution crystal structure of the human pparalpha ligand binding domain bound with gw409544 and a coactivator peptide | Transcription
