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1t4f
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1t4f]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T4F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1T4F FirstGlance]. <br> | <table><tr><td colspan='2'>[[1t4f]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T4F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1T4F FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1t4e|1t4e]], [[1ycr|1ycr]], [[1rv1|1rv1]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1t4e|1t4e]], [[1ycr|1ycr]], [[1rv1|1rv1]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MDM2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MDM2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1t4f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t4f OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1t4f RCSB], [http://www.ebi.ac.uk/pdbsum/1t4f PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1t4f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t4f OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1t4f RCSB], [http://www.ebi.ac.uk/pdbsum/1t4f PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
== Disease == | == Disease == | ||
[[http://www.uniprot.org/uniprot/MDM2_HUMAN MDM2_HUMAN]] Note=Seems to be amplified in certain tumors (including soft tissue sarcomas, osteosarcomas and gliomas). A higher frequency of splice variants lacking p53 binding domain sequences was found in late-stage and high-grade ovarian and bladder carcinomas. Four of the splice variants show loss of p53 binding. | [[http://www.uniprot.org/uniprot/MDM2_HUMAN MDM2_HUMAN]] Note=Seems to be amplified in certain tumors (including soft tissue sarcomas, osteosarcomas and gliomas). A higher frequency of splice variants lacking p53 binding domain sequences was found in late-stage and high-grade ovarian and bladder carcinomas. Four of the splice variants show loss of p53 binding. | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Carver, T E | + | [[Category: Carver, T E]] |
| - | [[Category: Franks, C F | + | [[Category: Franks, C F]] |
| - | [[Category: Grasberger, B L | + | [[Category: Grasberger, B L]] |
| - | [[Category: Koblish, H K | + | [[Category: Koblish, H K]] |
| - | [[Category: LaFrance, L V | + | [[Category: LaFrance, L V]] |
| - | [[Category: Lu, T | + | [[Category: Lu, T]] |
| - | [[Category: Parks, D J | + | [[Category: Parks, D J]] |
| - | [[Category: Schubert, C | + | [[Category: Schubert, C]] |
| - | [[Category: Zhao, S Y | + | [[Category: Zhao, S Y]] |
[[Category: Ligase]] | [[Category: Ligase]] | ||
[[Category: Mdm2-p53 peptide complex]] | [[Category: Mdm2-p53 peptide complex]] | ||
[[Category: P53-binding protein mdm2 oncoprotein mdm2 double minute 2 protein hdm2]] | [[Category: P53-binding protein mdm2 oncoprotein mdm2 double minute 2 protein hdm2]] | ||
Revision as of 07:25, 6 January 2015
Structure of human MDM2 in complex with an optimized p53 peptide
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