2il9
From Proteopedia
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| - | [[Image:2il9.gif|left|200px]] | + | [[Image:2il9.gif|left|200px]] |
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| - | '''Crystal Structure of Plautia Stali Intestine Virus Intergenic Region Internal Ribosome Entry Site Ribosomal Binding Domain RNA at 3.1 Angstroms''' | + | {{Structure |
| + | |PDB= 2il9 |SIZE=350|CAPTION= <scene name='initialview01'>2il9</scene>, resolution 3.100Å | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''Crystal Structure of Plautia Stali Intestine Virus Intergenic Region Internal Ribosome Entry Site Ribosomal Binding Domain RNA at 3.1 Angstroms''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2IL9 is a [ | + | 2IL9 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IL9 OCA]. |
==Reference== | ==Reference== | ||
| - | Structural basis for ribosome recruitment and manipulation by a viral IRES RNA., Pfingsten JS, Costantino DA, Kieft JS, Science. 2006 Dec 1;314(5804):1450-4. Epub 2006 Nov 23. PMID:[http:// | + | Structural basis for ribosome recruitment and manipulation by a viral IRES RNA., Pfingsten JS, Costantino DA, Kieft JS, Science. 2006 Dec 1;314(5804):1450-4. Epub 2006 Nov 23. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17124290 17124290] |
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Costantino, D A.]] | [[Category: Costantino, D A.]] | ||
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[[Category: rna; ires; ribosomal binding domain; psiv; under wound helix; double-nested pseudoknot]] | [[Category: rna; ires; ribosomal binding domain; psiv; under wound helix; double-nested pseudoknot]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:30:46 2008'' |
Revision as of 15:30, 20 March 2008
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| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal Structure of Plautia Stali Intestine Virus Intergenic Region Internal Ribosome Entry Site Ribosomal Binding Domain RNA at 3.1 Angstroms
Overview
Canonical cap-dependent translation initiation requires a large number of protein factors that act in a stepwise assembly process. In contrast, internal ribosomal entry sites (IRESs) are cis-acting RNAs that in some cases completely supplant these factors by recruiting and activating the ribosome using a single structured RNA. Here we present the crystal structures of the ribosome-binding domain from a Dicistroviridae intergenic region IRES at 3.1 angstrom resolution, providing a view of the prefolded architecture of an all-RNA translation initiation apparatus. Docking of the structure into cryo-electron microscopy reconstructions of an IRES-ribosome complex suggests a model for ribosome manipulation by a dynamic IRES RNA.
About this Structure
2IL9 is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.
Reference
Structural basis for ribosome recruitment and manipulation by a viral IRES RNA., Pfingsten JS, Costantino DA, Kieft JS, Science. 2006 Dec 1;314(5804):1450-4. Epub 2006 Nov 23. PMID:17124290
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