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1yok
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1yok]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YOK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1YOK FirstGlance]. <br> | <table><tr><td colspan='2'>[[1yok]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YOK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1YOK FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=P6L:(2S)-3-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-2-[(6E)-HEXADEC-6-ENOYLOXY]PROPYL+(8E)-OCTADEC-8-ENOATE'>P6L</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=P6L:(2S)-3-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-2-[(6E)-HEXADEC-6-ENOYLOXY]PROPYL+(8E)-OCTADEC-8-ENOATE'>P6L</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1ymt|1ymt]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1ymt|1ymt]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NR5A2, B1F, CPF, FTF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NR5A2, B1F, CPF, FTF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1yok FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yok OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1yok RCSB], [http://www.ebi.ac.uk/pdbsum/1yok PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1yok FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yok OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1yok RCSB], [http://www.ebi.ac.uk/pdbsum/1yok PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
== Disease == | == Disease == | ||
[[http://www.uniprot.org/uniprot/NCOA2_HUMAN NCOA2_HUMAN]] Note=Chromosomal aberrations involving NCOA2 may be a cause of acute myeloid leukemias. Inversion inv(8)(p11;q13) generates the KAT6A-NCOA2 oncogene, which consists of the N-terminal part of KAT6A and the C-terminal part of NCOA2/TIF2. KAT6A-NCOA2 binds to CREBBP and disrupts its function in transcription activation. | [[http://www.uniprot.org/uniprot/NCOA2_HUMAN NCOA2_HUMAN]] Note=Chromosomal aberrations involving NCOA2 may be a cause of acute myeloid leukemias. Inversion inv(8)(p11;q13) generates the KAT6A-NCOA2 oncogene, which consists of the N-terminal part of KAT6A and the C-terminal part of NCOA2/TIF2. KAT6A-NCOA2 binds to CREBBP and disrupts its function in transcription activation. | ||
| Line 35: | Line 35: | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Bynum, J M | + | [[Category: Bynum, J M]] |
| - | [[Category: Fletterick, R J | + | [[Category: Fletterick, R J]] |
| - | [[Category: Guy, R K | + | [[Category: Guy, R K]] |
| - | [[Category: Ingraham, H A | + | [[Category: Ingraham, H A]] |
| - | [[Category: Juzumiene, D | + | [[Category: Juzumiene, D]] |
| - | [[Category: Krylova, I N | + | [[Category: Krylova, I N]] |
| - | [[Category: Lebedeva, L | + | [[Category: Lebedeva, L]] |
| - | [[Category: MacKay, J A | + | [[Category: MacKay, J A]] |
| - | [[Category: Madauss, K | + | [[Category: Madauss, K]] |
| - | [[Category: Montana, V | + | [[Category: Montana, V]] |
| - | [[Category: Moore, J | + | [[Category: Moore, J]] |
| - | [[Category: Sablin, E P | + | [[Category: Sablin, E P]] |
| - | [[Category: Suzawa, M | + | [[Category: Suzawa, M]] |
| - | [[Category: Thornton, J W | + | [[Category: Thornton, J W]] |
| - | [[Category: Waitt, G M | + | [[Category: Waitt, G M]] |
| - | [[Category: Williams, J D | + | [[Category: Williams, J D]] |
| - | [[Category: Williams, S P | + | [[Category: Williams, S P]] |
| - | [[Category: Willson, T M | + | [[Category: Willson, T M]] |
| - | [[Category: Xu, R X | + | [[Category: Xu, R X]] |
[[Category: Lrh-1]] | [[Category: Lrh-1]] | ||
[[Category: Phosphatidylglycerol]] | [[Category: Phosphatidylglycerol]] | ||
[[Category: Tif-1]] | [[Category: Tif-1]] | ||
[[Category: Transcription]] | [[Category: Transcription]] | ||
Revision as of 09:59, 8 January 2015
crystal structure of human LRH-1 bound with TIF-2 peptide and phosphatidylglycerol
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Categories: Homo sapiens | Bynum, J M | Fletterick, R J | Guy, R K | Ingraham, H A | Juzumiene, D | Krylova, I N | Lebedeva, L | MacKay, J A | Madauss, K | Montana, V | Moore, J | Sablin, E P | Suzawa, M | Thornton, J W | Waitt, G M | Williams, J D | Williams, S P | Willson, T M | Xu, R X | Lrh-1 | Phosphatidylglycerol | Tif-1 | Transcription
