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1yk8
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1yk8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YK8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1YK8 FirstGlance]. <br> | <table><tr><td colspan='2'>[[1yk8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YK8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1YK8 FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=T2M:TERT-BUTYL+2-CYANO-2-METHYLHYDRAZINECARBOXYLATE'>T2M</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=T2M:TERT-BUTYL+2-CYANO-2-METHYLHYDRAZINECARBOXYLATE'>T2M</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CTSK, CTSO, CTSO2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CTSK, CTSO, CTSO2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> |
| - | <tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cathepsin_K Cathepsin K], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.38 3.4.22.38] </span></td></tr> | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cathepsin_K Cathepsin K], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.38 3.4.22.38] </span></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1yk8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yk8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1yk8 RCSB], [http://www.ebi.ac.uk/pdbsum/1yk8 PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1yk8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yk8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1yk8 RCSB], [http://www.ebi.ac.uk/pdbsum/1yk8 PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
== Disease == | == Disease == | ||
[[http://www.uniprot.org/uniprot/CATK_HUMAN CATK_HUMAN]] Defects in CTSK are the cause of pycnodysostosis (PKND) [MIM:[http://omim.org/entry/265800 265800]]. PKND is an autosomal recessive osteochondrodysplasia characterized by osteosclerosis and short stature.<ref>PMID:8703060</ref> <ref>PMID:9529353</ref> <ref>PMID:10491211</ref> <ref>PMID:10878663</ref> | [[http://www.uniprot.org/uniprot/CATK_HUMAN CATK_HUMAN]] Defects in CTSK are the cause of pycnodysostosis (PKND) [MIM:[http://omim.org/entry/265800 265800]]. PKND is an autosomal recessive osteochondrodysplasia characterized by osteosclerosis and short stature.<ref>PMID:8703060</ref> <ref>PMID:9529353</ref> <ref>PMID:10491211</ref> <ref>PMID:10878663</ref> | ||
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[[Category: Cathepsin K]] | [[Category: Cathepsin K]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Barrett, D G | + | [[Category: Barrett, D G]] |
| - | [[Category: Deaton, D N | + | [[Category: Deaton, D N]] |
| - | [[Category: Hassell, A M | + | [[Category: Hassell, A M]] |
| - | [[Category: McFadyen, R B | + | [[Category: McFadyen, R B]] |
| - | [[Category: Miller, A B | + | [[Category: Miller, A B]] |
| - | [[Category: Miller, L R | + | [[Category: Miller, L R]] |
| - | [[Category: Payne, J A | + | [[Category: Payne, J A]] |
| - | [[Category: Shewchuk, L M | + | [[Category: Shewchuk, L M]] |
| - | [[Category: Willard, D H | + | [[Category: Willard, D H]] |
| - | [[Category: Wright, L L | + | [[Category: Wright, L L]] |
[[Category: Cathepsin]] | [[Category: Cathepsin]] | ||
[[Category: Catk]] | [[Category: Catk]] | ||
Revision as of 10:10, 8 January 2015
Cathepsin K complexed with a cyanamide-based inhibitor
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Categories: Cathepsin K | Homo sapiens | Barrett, D G | Deaton, D N | Hassell, A M | McFadyen, R B | Miller, A B | Miller, L R | Payne, J A | Shewchuk, L M | Willard, D H | Wright, L L | Cathepsin | Catk | Cysteine | Hydrolase | Protease
