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2j45

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[[Image:2j45.jpg|left|200px]]<br /><applet load="2j45" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:2j45.jpg|left|200px]]
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caption="2j45, resolution 1.14&Aring;" />
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'''WATER STRUCTURE OF T. AQUATICUS FFH NG DOMAIN AT 1.1A RESOLUTION'''<br />
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{{Structure
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|PDB= 2j45 |SIZE=350|CAPTION= <scene name='initialview01'>2j45</scene>, resolution 1.14&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MRD:(4R)-2-METHYLPENTANE-2,4-DIOL'>MRD</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene> and <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''WATER STRUCTURE OF T. AQUATICUS FFH NG DOMAIN AT 1.1A RESOLUTION'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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2J45 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Thermus_aquaticus Thermus aquaticus] with <scene name='pdbligand=NA:'>NA</scene>, <scene name='pdbligand=CA:'>CA</scene>, <scene name='pdbligand=MRD:'>MRD</scene>, <scene name='pdbligand=MES:'>MES</scene> and <scene name='pdbligand=EDO:'>EDO</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J45 OCA].
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2J45 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Thermus_aquaticus Thermus aquaticus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J45 OCA].
==Reference==
==Reference==
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Analysis of protein hydration in ultrahigh-resolution structures of the SRP GTPase Ffh., Ramirez UD, Freymann DM, Acta Crystallogr D Biol Crystallogr. 2006 Dec;62(Pt 12):1520-34. Epub 2006, Nov 23. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17139088 17139088]
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Analysis of protein hydration in ultrahigh-resolution structures of the SRP GTPase Ffh., Ramirez UD, Freymann DM, Acta Crystallogr D Biol Crystallogr. 2006 Dec;62(Pt 12):1520-34. Epub 2006, Nov 23. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17139088 17139088]
[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Thermus aquaticus]]
[[Category: Thermus aquaticus]]
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[[Category: water]]
[[Category: water]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:58:59 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:36:56 2008''

Revision as of 15:36, 20 March 2008

Image:2j45.jpg


PDB ID 2j45

Drag the structure with the mouse to rotate
, resolution 1.14Å
Ligands: , , , and
Coordinates: save as pdb, mmCIF, xml



WATER STRUCTURE OF T. AQUATICUS FFH NG DOMAIN AT 1.1A RESOLUTION


Overview

Two new structures of the SRP GTPase Ffh have been determined at 1.1 A resolution and provide the basis for comparative examination of the extensive water structure of the apo conformation of these GTPases. A set of well defined water-binding positions have been identified in the active site of the two-domain ;NG' GTPase, as well as at two functionally important interfaces. The water hydrogen-bonding network accommodates alternate conformations of the protein side chains by undergoing local rearrangements and, in one case, illustrates binding of a solute molecule within the active site by displacement of water molecules without further disruption of the water-interaction network. A subset of the water positions are well defined in several lower resolution structures, including those of different nucleotide-binding states; these appear to function in maintaining the protein structure. Consistent arrangements of surface water between three different ultrahigh-resolution structures provide a framework for beginning to understand how local water structure contributes to protein-ligand and protein-protein binding in the SRP GTPases.

About this Structure

2J45 is a Single protein structure of sequence from Thermus aquaticus. Full crystallographic information is available from OCA.

Reference

Analysis of protein hydration in ultrahigh-resolution structures of the SRP GTPase Ffh., Ramirez UD, Freymann DM, Acta Crystallogr D Biol Crystallogr. 2006 Dec;62(Pt 12):1520-34. Epub 2006, Nov 23. PMID:17139088

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