This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
4oep
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | ''' | + | ==Crystal structure of the ZO-1 PDZ1 domain in complex with the 7-mer Claudin1 C-terminal tail== |
| - | + | <StructureSection load='4oep' size='340' side='right' caption='[[4oep]], [[Resolution|resolution]] 2.35Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4oep]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OEP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OEP FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=12P:DODECAETHYLENE+GLYCOL'>12P</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene></td></tr> | |
| - | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4oeo|4oeo]], [[4oeq|4oeq]]</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4oep FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oep OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4oep RCSB], [http://www.ebi.ac.uk/pdbsum/4oep PDBsum]</span></td></tr> | |
| - | + | </table> | |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/ZO1_HUMAN ZO1_HUMAN]] The N-terminal may be involved in transducing a signal required for tight junction assembly, while the C-terminal may have specific properties of tight junctions. The alpha domain might be involved in stabilizing junctions. Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells.<ref>PMID:21240187</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Lavie, A]] | [[Category: Lavie, A]] | ||
[[Category: Nomme, J]] | [[Category: Nomme, J]] | ||
| + | [[Category: Cell adhesion]] | ||
| + | [[Category: Claudin]] | ||
| + | [[Category: Maguk]] | ||
| + | [[Category: Pdz1]] | ||
| + | [[Category: Scaffolding]] | ||
| + | [[Category: Tight junction assembly]] | ||
Revision as of 13:42, 14 January 2015
Crystal structure of the ZO-1 PDZ1 domain in complex with the 7-mer Claudin1 C-terminal tail
| |||||||||||
Categories: Lavie, A | Nomme, J | Cell adhesion | Claudin | Maguk | Pdz1 | Scaffolding | Tight junction assembly
