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2jun
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2jun]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JUN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JUN FirstGlance]. <br> | <table><tr><td colspan='2'>[[2jun]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JUN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JUN FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MID1, FXY, RNF59, TRIM18, XPRF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MID1, FXY, RNF59, TRIM18, XPRF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jun FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jun OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jun RCSB], [http://www.ebi.ac.uk/pdbsum/2jun PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jun FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jun OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jun RCSB], [http://www.ebi.ac.uk/pdbsum/2jun PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
== Disease == | == Disease == | ||
[[http://www.uniprot.org/uniprot/TRI18_HUMAN TRI18_HUMAN]] Defects in MID1 are the cause of Opitz GBBB syndrome 1 (OGS1) [MIM:[http://omim.org/entry/300000 300000]]. A congenital midline malformation syndrome characterized by hypertelorism, genital-urinary defects such as hypospadias in males and splayed labia in females, lip-palate-laryngotracheal clefts, imperforate anus, developmental delay and congenital heart defects. Note=MID1 mutations produce proteins with a decreased affinity for microtubules.<ref>PMID:9354791</ref> <ref>PMID:11030761</ref> <ref>PMID:9718340</ref> <ref>PMID:15558842</ref> | [[http://www.uniprot.org/uniprot/TRI18_HUMAN TRI18_HUMAN]] Defects in MID1 are the cause of Opitz GBBB syndrome 1 (OGS1) [MIM:[http://omim.org/entry/300000 300000]]. A congenital midline malformation syndrome characterized by hypertelorism, genital-urinary defects such as hypospadias in males and splayed labia in females, lip-palate-laryngotracheal clefts, imperforate anus, developmental delay and congenital heart defects. Note=MID1 mutations produce proteins with a decreased affinity for microtubules.<ref>PMID:9354791</ref> <ref>PMID:11030761</ref> <ref>PMID:9718340</ref> <ref>PMID:15558842</ref> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Cox, T C | + | [[Category: Cox, T C]] |
| - | [[Category: Jakkidi, M | + | [[Category: Jakkidi, M]] |
| - | [[Category: Massiah, M A | + | [[Category: Massiah, M A]] |
| - | [[Category: Short, K M | + | [[Category: Short, K M]] |
| - | [[Category: Simmons, B N | + | [[Category: Simmons, B N]] |
| - | [[Category: Singireddy, S | + | [[Category: Singireddy, S]] |
| - | [[Category: Tao, H | + | [[Category: Tao, H]] |
[[Category: B-box]] | [[Category: B-box]] | ||
[[Category: Cytoskeleton]] | [[Category: Cytoskeleton]] | ||
Revision as of 14:43, 19 January 2015
Structure of the MID1 tandem B-boxes reveals an interaction reminiscent of intermolecular RING heterodimers
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Categories: Homo sapiens | Cox, T C | Jakkidi, M | Massiah, M A | Short, K M | Simmons, B N | Singireddy, S | Tao, H | B-box | Cytoskeleton | Disease mutation | Ligase | Metal-binding | Microtubule | Midline 1 | Phosphorylation | Ring finger | Trim | Ubl conjugation pathway | Zinc-finger

