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2jk7
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2jk7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JK7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JK7 FirstGlance]. <br> | <table><tr><td colspan='2'>[[2jk7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JK7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JK7 FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BI6:(3S,6S,7Z,10AS)-N-(DIPHENYLMETHYL)-6-{[(2S)-2-(METHYLIDENEAMINO)BUTANOYL]AMINO}-5-OXO-1,2,3,5,6,9,10,10A-OCTAHYDROPYRROLO[1,2-A]AZOCINE-3-CARBOXAMIDE'>BI6</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BI6:(3S,6S,7Z,10AS)-N-(DIPHENYLMETHYL)-6-{[(2S)-2-(METHYLIDENEAMINO)BUTANOYL]AMINO}-5-OXO-1,2,3,5,6,9,10,10A-OCTAHYDROPYRROLO[1,2-A]AZOCINE-3-CARBOXAMIDE'>BI6</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1kmc|1kmc]], [[1f9x|1f9x]], [[1g73|1g73]], [[1i4o|1i4o]], [[2vsl|2vsl]], [[1tfq|1tfq]], [[1tft|1tft]], [[1c9q|1c9q]], [[1nw9|1nw9]], [[1i3o|1i3o]], [[1i51|1i51]], [[1g3f|1g3f]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1kmc|1kmc]], [[1f9x|1f9x]], [[1g73|1g73]], [[1i4o|1i4o]], [[2vsl|2vsl]], [[1tfq|1tfq]], [[1tft|1tft]], [[1c9q|1c9q]], [[1nw9|1nw9]], [[1i3o|1i3o]], [[1i51|1i51]], [[1g3f|1g3f]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jk7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jk7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jk7 RCSB], [http://www.ebi.ac.uk/pdbsum/2jk7 PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jk7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jk7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jk7 RCSB], [http://www.ebi.ac.uk/pdbsum/2jk7 PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
== Disease == | == Disease == | ||
[[http://www.uniprot.org/uniprot/BIRC4_HUMAN BIRC4_HUMAN]] Defects in XIAP are the cause of lymphoproliferative syndrome X-linked type 2 (XLP2) [MIM:[http://omim.org/entry/300635 300635]]. XLP is a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus (EBV). Symptoms include severe or fatal mononucleosis, acquired hypogammaglobulinemia, pancytopenia and malignant lymphoma.<ref>PMID:17080092</ref> | [[http://www.uniprot.org/uniprot/BIRC4_HUMAN BIRC4_HUMAN]] Defects in XIAP are the cause of lymphoproliferative syndrome X-linked type 2 (XLP2) [MIM:[http://omim.org/entry/300635 300635]]. XLP is a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus (EBV). Symptoms include severe or fatal mononucleosis, acquired hypogammaglobulinemia, pancytopenia and malignant lymphoma.<ref>PMID:17080092</ref> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Meagher, J L | + | [[Category: Meagher, J L]] |
| - | [[Category: Saito, N G | + | [[Category: Saito, N G]] |
| - | [[Category: Stuckey, J A | + | [[Category: Stuckey, J A]] |
[[Category: Apoptosis]] | [[Category: Apoptosis]] | ||
[[Category: Bir3]] | [[Category: Bir3]] | ||
Revision as of 16:35, 19 January 2015
XIAP BIR3 BOUND TO A SMAC MIMETIC
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