Aminopeptidase

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Line 42: Line 42:
**[[3ebh]] - PfAla-AP+bestatin<br />
**[[3ebh]] - PfAla-AP+bestatin<br />
**[[3ebi]] - PfAla-AP+dipeptide analog<br />
**[[3ebi]] - PfAla-AP+dipeptide analog<br />
 +
**[[4r5t]], [[4r5v]], [[4r5x]] – PfAla-AP + inhibitor <br />
**[[4fke]] – pAla-AP + Zn – pig<br />
**[[4fke]] – pAla-AP + Zn – pig<br />
**[[4fkh]] – pAla-AP + Zn + alanine<br />
**[[4fkh]] – pAla-AP + Zn + alanine<br />
Line 57: Line 58:
**[[2zxg]] – EcAPN+transition state analog<br />
**[[2zxg]] – EcAPN+transition state analog<br />
**[[3b2p]], [[3b2x]], [[3b34]], [[3b37]], [[3b3b]], [[3qjx]] – EcAPN+amino acid<br />
**[[3b2p]], [[3b2x]], [[3b34]], [[3b37]], [[3b3b]], [[3qjx]] – EcAPN+amino acid<br />
-
**[[2gtq]] – APN – ''Neisseria meningitides''
+
**[[2gtq]] – NmAPN – ''Neisseria meningitides''
*Proline aminopeptidase
*Proline aminopeptidase
Line 78: Line 79:
**[[3ig4]] - Xaa Pro-AP+ Mn – ''Bacillus anthracis''<br />
**[[3ig4]] - Xaa Pro-AP+ Mn – ''Bacillus anthracis''<br />
**[[4fkc]] – Xaa Pro-AP + Cd – ''Thermococcus sibiricus''<br />
**[[4fkc]] – Xaa Pro-AP + Cd – ''Thermococcus sibiricus''<br />
 +
4pv4]] – Pro-AP II + Mg – ''Yersinia pestis''<br />
**[[2zsg]] – X TmPro-AP – ''Thermatoga maritima''<br />
**[[2zsg]] – X TmPro-AP – ''Thermatoga maritima''<br />
**[[3ctz]] – X hPro-AP <br />
**[[3ctz]] – X hPro-AP <br />
Line 117: Line 119:
**[[1gyt]] – EcLeu-AP<br />
**[[1gyt]] – EcLeu-AP<br />
**[[3qnf]] – hLeu-AP 1<br />
**[[3qnf]] – hLeu-AP 1<br />
-
**[[3t8w]], [[4k3n]] – PfLeu-AP + Zn + inhibitor – ''Plasmodium falciparum''<br />
+
**[[3t8w]], [[4k3n]], [[4r6t]] – PfLeu-AP + Zn + inhibitor <br />
 +
**[[4r76]], [[4r7m]] – PfLeu-AP (mutant) + Zn + inhibitor <br />
**[[3tc8]] - PdLeu-AP + Zn<br />
**[[3tc8]] - PdLeu-AP + Zn<br />
**[[4fuu]] - Leu-AP + Zn – ''Bacterioides thetaiotaomicron''<br />
**[[4fuu]] - Leu-AP + Zn – ''Bacterioides thetaiotaomicron''<br />
**[[4ksi]] – Leu-AP + Mg – tomato<br />
**[[4ksi]] – Leu-AP + Mg – tomato<br />
 +
 +
*Leucine-cysteine aminopeptidase
 +
 +
**[[4p8q]] – hLeu-Cys-AP + Zn<br />
 +
**[[4pj6]] – hLeu-Cys-AP + Zn + lysine<br />
 +
*Methionine aminopeptidase
*Methionine aminopeptidase
Line 127: Line 136:
**[[2dfi]], [[1xgm]], [[1xgn]], [[1xgo]], [[1xgs]] – PfMet-AP+Co – ''Pyrococcus furiosus''<br />
**[[2dfi]], [[1xgm]], [[1xgn]], [[1xgo]], [[1xgs]] – PfMet-AP+Co – ''Pyrococcus furiosus''<br />
**[[1wkm]] - PfMet-AP+Mn<br />
**[[1wkm]] - PfMet-AP+Mn<br />
-
**[[4fo7]] - PaMet-AP+Mn – ''Pseudomonas aeruginosa''<br />
+
**[[4fo7]], [[4juq]] - PaMet-AP+Mn – ''Pseudomonas aeruginosa''<br />
**[[4fo8]] - PaMet-AP+Mn + Met <br />
**[[4fo8]] - PaMet-AP+Mn + Met <br />
**[[4hxx]], [[4iu6]] - hMet-AP+ Co + pyrimidine derivative<br />
**[[4hxx]], [[4iu6]] - hMet-AP+ Co + pyrimidine derivative<br />
Line 142: Line 151:
**[[3fmq]], [[3fmr]] - EncMet-AP+angiogenesis inhibitor<br />
**[[3fmq]], [[3fmr]] - EncMet-AP+angiogenesis inhibitor<br />
**[[3d27]], [[2q92]], [[2q93]], [[2q94]], [[2q95]], [[2q96]], [[2p98]], [[2p99]], [[2p9a]], [[2gu4]], [[2gu5]], [[2gu6]], [[2evc]], [[2evm]], [[2evo]], [[2bbv]], [[1xnz]], [[4a6v]], [[4a6w]], [[2bb7]] – EcMet-AP+Mn+inhibitor<br />
**[[3d27]], [[2q92]], [[2q93]], [[2q94]], [[2q95]], [[2q96]], [[2p98]], [[2p99]], [[2p9a]], [[2gu4]], [[2gu5]], [[2gu6]], [[2evc]], [[2evm]], [[2evo]], [[2bbv]], [[1xnz]], [[4a6v]], [[4a6w]], [[2bb7]] – EcMet-AP+Mn+inhibitor<br />
-
**[[2gg0]], [[2gg2]], [[2gg3]], [[2gg5]], [[2gg7]], [[2gg8]], [[2gg9]], [[2ggb]], [[2ggc]] - EcMet-AP+Co+inhibitor<br />
+
**[[2gg0]], [[2gg2]], [[2gg3]], [[2gg5]], [[2gg7]], [[2gg8]], [[2gg9]], [[2ggb]], [[2ggc]], [[4pnc]] - EcMet-AP+Co+inhibitor<br />
**[[1c21]], [[1c22]], [[1c23]], [[1c24]] - EcMet-AP +Co + methionine derivative<br />
**[[1c21]], [[1c22]], [[1c23]], [[1c24]] - EcMet-AP +Co + methionine derivative<br />
**[[1c27]] - EcMet-AP +Co +norleucine<br />
**[[1c27]] - EcMet-AP +Co +norleucine<br />
Line 212: Line 221:
**[[4icr]] – SpAP Peps (mutant) + Zn<br />
**[[4icr]] – SpAP Peps (mutant) + Zn<br />
**[[4ics]] – SpAP Peps (mutant) + Zn + Trp + Gly<br />
**[[4ics]] – SpAP Peps (mutant) + Zn + Trp + Gly<br />
 +
**[[4pu2]], [[4pvb]] – NmAP N + Leu analog <br />
 +
**[[4pw4]] – NmAP N + Phe analog <br />
 +
**[[4qhp]], [[4qir]], [[4qme]], [[4qpe]], [[4quo]] – NmAP N + dipeptide analog <br />
*Cold-activated aminopeptidase
*Cold-activated aminopeptidase

Revision as of 13:26, 28 January 2015

Bacterial leucine aminopeptidase complex with 8-hydroxyquinoline, glycerol, SCN, Zn+2 (magenta), Na+ (cyan) and Cl- (green) ions (PDB code 3vh9)

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3D Structures of Aminopeptidase

Updated on 28-January-2015

4pv4]] – Pro-AP II + Mg – Yersinia pestis


Additional Resources

For additional information, see:
Amino Acid Synthesis & Metabolism
Streptomyces griseus Aminopeptidase (SGAP)

References

  1. ↑ Hanaya K, Suetsugu M, Saijo S, Yamato I, Aoki S. Potent inhibition of dinuclear zinc(II) peptidase, an aminopeptidase from Aeromonas proteolytica, by 8-quinolinol derivatives: inhibitor design based on Zn(2+) fluorophores, kinetic, and X-ray crystallographic study. J Biol Inorg Chem. 2012 Feb 5. PMID:22311113 doi:10.1007/s00775-012-0873-4

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, David Canner, Joel L. Sussman, Eran Hodis

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