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2plb

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[[Image:2plb.gif|left|200px]]<br /><applet load="2plb" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:2plb.gif|left|200px]]
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caption="2plb, resolution 1.60&Aring;" />
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'''D(GTATACC) under hydrostatic pressure of 1.39 GPa'''<br />
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{{Structure
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|PDB= 2plb |SIZE=350|CAPTION= <scene name='initialview01'>2plb</scene>, resolution 1.60&Aring;
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|SITE= <scene name='pdbsite=AC1:Spm+Binding+Site+For+Residue+B+20'>AC1</scene>
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|LIGAND= <scene name='pdbligand=SPM:SPERMINE'>SPM</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''D(GTATACC) under hydrostatic pressure of 1.39 GPa'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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2PLB is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ] with <scene name='pdbligand=SPM:'>SPM</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Known structural/functional Site: <scene name='pdbsite=AC1:Spm+Binding+Site+For+Residue+B+20'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PLB OCA].
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2PLB is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PLB OCA].
==Reference==
==Reference==
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Adaptation of the base-paired double-helix molecular architecture to extreme pressure., Girard E, Prange T, Dhaussy AC, Migianu-Griffoni E, Lecouvey M, Chervin JC, Mezouar M, Kahn R, Fourme R, Nucleic Acids Res. 2007;35(14):4800-8. Epub 2007 Jul 7. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17617642 17617642]
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Adaptation of the base-paired double-helix molecular architecture to extreme pressure., Girard E, Prange T, Dhaussy AC, Migianu-Griffoni E, Lecouvey M, Chervin JC, Mezouar M, Kahn R, Fourme R, Nucleic Acids Res. 2007;35(14):4800-8. Epub 2007 Jul 7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17617642 17617642]
[[Category: Protein complex]]
[[Category: Protein complex]]
[[Category: Fourme, R.]]
[[Category: Fourme, R.]]
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[[Category: high-pressure]]
[[Category: high-pressure]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:30:39 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:14:25 2008''

Revision as of 16:14, 20 March 2008

Image:2plb.gif


PDB ID 2plb

Drag the structure with the mouse to rotate
, resolution 1.60Å
Sites:
Ligands:
Coordinates: save as pdb, mmCIF, xml



D(GTATACC) under hydrostatic pressure of 1.39 GPa


Overview

The behaviour of the d(GGTATACC) oligonucleotide has been investigated by X-ray crystallography at 295 K in the range from ambient pressure to 2 GPa (approximately 20,000 atm). Four 3D-structures of the A-DNA form (at ambient pressure, 0.55, 1.09 and 1.39 GPa) were refined at 1.60 or 1.65 A resolution. In addition to the diffraction pattern of the A-form, the broad meridional streaks previously explained by occluded B-DNA octamers within the channels of the crystalline A-form matrix were observed up to at least 2 GPa. This work highlights an important property of nucleic acids, their capability to withstand very high pressures, while keeping in such conditions a nearly invariant geometry of base pairs that store and carry genetic information. The double-helix base-paired architecture behaves as a molecular spring, which makes it especially adapted to very harsh conditions. These features may have contributed to the emergence of a RNA World at prebiotic stage.

About this Structure

2PLB is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.

Reference

Adaptation of the base-paired double-helix molecular architecture to extreme pressure., Girard E, Prange T, Dhaussy AC, Migianu-Griffoni E, Lecouvey M, Chervin JC, Mezouar M, Kahn R, Fourme R, Nucleic Acids Res. 2007;35(14):4800-8. Epub 2007 Jul 7. PMID:17617642

Page seeded by OCA on Thu Mar 20 18:14:25 2008

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