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2mr9
From Proteopedia
(Difference between revisions)
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| - | ''' | + | ==NMR structure of UBA domain of DNA-damage-inducible 1 protein (Ddi1)== |
| - | + | <StructureSection load='2mr9' size='340' side='right' caption='[[2mr9]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[2mr9]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MR9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MR9 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mr9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mr9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2mr9 RCSB], [http://www.ebi.ac.uk/pdbsum/2mr9 PDBsum]</span></td></tr> | |
| - | + | </table> | |
| - | + | == Function == | |
| - | [[ | + | [[http://www.uniprot.org/uniprot/DDI1_YEAST DDI1_YEAST]] Acts as a linker between the 19S proteasome and polyubiquitinated proteins like the HO endonuclease and UFO1 via UBA domain interactions with ubiquitin for their subsequent degradation. Required for S-phase checkpoint control. Appears to act as negative regulator of constitutive exocytosis. May act at the level of secretory vesicle docking and fusion as a competitive inhibitor of SNARE assembly.<ref>PMID:10330187</ref> <ref>PMID:11238935</ref> <ref>PMID:12051757</ref> <ref>PMID:12925750</ref> <ref>PMID:15964793</ref> <ref>PMID:17144915</ref> <ref>PMID:16478980</ref> |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Fushman, D]] | [[Category: Fushman, D]] | ||
[[Category: Zhang, D]] | [[Category: Zhang, D]] | ||
| + | [[Category: Ddi1]] | ||
| + | [[Category: Dna-damage-inducible 1 protein]] | ||
| + | [[Category: Hydrolase]] | ||
| + | [[Category: Uba]] | ||
| + | [[Category: Ubiquitin associated domain]] | ||
Revision as of 15:52, 7 February 2015
NMR structure of UBA domain of DNA-damage-inducible 1 protein (Ddi1)
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