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4rsu
From Proteopedia
(Difference between revisions)
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| - | ''' | + | ==Crystal structure of the light and hvem complex== |
| - | + | <StructureSection load='4rsu' size='340' side='right' caption='[[4rsu]], [[Resolution|resolution]] 2.30Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4rsu]] is a 12 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RSU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RSU FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | |
| - | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4j6g|4j6g]], [[4fhq|4fhq]], [[2aw2|2aw2]]</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rsu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rsu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4rsu RCSB], [http://www.ebi.ac.uk/pdbsum/4rsu PDBsum]</span></td></tr> | |
| - | [[ | + | </table> |
| - | [[Category: Almo, S | + | == Function == |
| - | [[Category: | + | [[http://www.uniprot.org/uniprot/TNF14_HUMAN TNF14_HUMAN]] Cytokine that binds to TNFRSF3/LTBR. Binding to the decoy receptor TNFRSF6B modulates its effects. Activates NFKB, stimulates the proliferation of T-cells, and inhibits growth of the adenocarcinoma HT-29. Acts as a receptor for Herpes simplex virus. [[http://www.uniprot.org/uniprot/TNR14_HUMAN TNR14_HUMAN]] Receptor for BTLA. Receptor for TNFSF14/LIGHT and homotrimeric TNFSF1/lymphotoxin-alpha. Involved in lymphocyte activation. Plays an important role in HSV pathogenesis because it enhanced the entry of several wild-type HSV strains of both serotypes into CHO cells, and mediated HSV entry into activated human T-cells.<ref>PMID:8898196</ref> |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Almo, S C]] | ||
| + | [[Category: Bonanno, J B]] | ||
[[Category: Himmel, D]] | [[Category: Himmel, D]] | ||
| - | [[Category: | + | [[Category: IFN, Atoms-to-Animals:.The Immune Function Network]] |
| - | [[Category: | + | [[Category: Liu, W]] |
| - | [[Category: Ramagoal, U | + | [[Category: Nathenson, S G]] |
| - | [[Category: Atoms- | + | [[Category: Ramagoal, U A]] |
| + | [[Category: Atoms-to-animals: the immune function network]] | ||
| + | [[Category: Cell membrane]] | ||
| + | [[Category: Cysteine rich domain]] | ||
| + | [[Category: Cytokine]] | ||
| + | [[Category: Ifn]] | ||
| + | [[Category: Immune system]] | ||
| + | [[Category: Immunity]] | ||
| + | [[Category: Jelly-roll fold]] | ||
| + | [[Category: Membrane]] | ||
| + | [[Category: N-glycosylation]] | ||
| + | [[Category: Structural genomic]] | ||
| + | [[Category: Nysgrc]] | ||
| + | [[Category: PSI, Protein structure initiative]] | ||
| + | [[Category: Psi-biology]] | ||
| + | [[Category: Research consortium]] | ||
| + | [[Category: Secreted]] | ||
| + | [[Category: Secreted protein]] | ||
| + | [[Category: Signaling]] | ||
Revision as of 15:58, 7 February 2015
Crystal structure of the light and hvem complex
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Categories: Almo, S C | Bonanno, J B | Himmel, D | IFN, Atoms-to-Animals:.The Immune Function Network | Liu, W | Nathenson, S G | Ramagoal, U A | Atoms-to-animals: the immune function network | Cell membrane | Cysteine rich domain | Cytokine | Ifn | Immune system | Immunity | Jelly-roll fold | Membrane | N-glycosylation | Structural genomic | Nysgrc | PSI, Protein structure initiative | Psi-biology | Research consortium | Secreted | Secreted protein | Signaling
