This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


4nyv

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
{{STRUCTURE_4nyv| PDB=4nyv | SCENE= }}
+
==Crystal Structure of the Bromodomain of human CREBBP in complex with a quinazolin-one ligand==
-
===Crystal Structure of the Bromodomain of human CREBBP in complex with a quinazolin-one ligand===
+
<StructureSection load='4nyv' size='340' side='right' caption='[[4nyv]], [[Resolution|resolution]] 1.83&Aring;' scene=''>
-
 
+
== Structural highlights ==
-
==Disease==
+
<table><tr><td colspan='2'>[[4nyv]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NYV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NYV FirstGlance]. <br>
 +
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=15E:6-BROMO-3-METHYL-3,4-DIHYDROQUINAZOLIN-2(1H)-ONE'>15E</scene></td></tr>
 +
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4nyw|4nyw]], [[4nyx|4nyx]]</td></tr>
 +
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CBP, CREBBP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nyv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nyv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4nyv RCSB], [http://www.ebi.ac.uk/pdbsum/4nyv PDBsum]</span></td></tr>
 +
</table>
 +
== Disease ==
[[http://www.uniprot.org/uniprot/CBP_HUMAN CBP_HUMAN]] Note=Chromosomal aberrations involving CREBBP may be a cause of acute myeloid leukemias. Translocation t(8;16)(p11;p13) with KAT6A; translocation t(11;16)(q23;p13.3) with MLL/HRX; translocation t(10;16)(q22;p13) with KAT6B. KAT6A-CREBBP may induce leukemia by inhibiting RUNX1-mediated transcription. Defects in CREBBP are a cause of Rubinstein-Taybi syndrome type 1 (RSTS1) [MIM:[http://omim.org/entry/180849 180849]]. RSTS1 is an autosomal dominant disorder characterized by craniofacial abnormalities, broad thumbs, broad big toes, mental retardation and a propensity for development of malignancies.<ref>PMID:11331617</ref> <ref>PMID:12114483</ref> <ref>PMID:12566391</ref> <ref>PMID:15706485</ref>
[[http://www.uniprot.org/uniprot/CBP_HUMAN CBP_HUMAN]] Note=Chromosomal aberrations involving CREBBP may be a cause of acute myeloid leukemias. Translocation t(8;16)(p11;p13) with KAT6A; translocation t(11;16)(q23;p13.3) with MLL/HRX; translocation t(10;16)(q22;p13) with KAT6B. KAT6A-CREBBP may induce leukemia by inhibiting RUNX1-mediated transcription. Defects in CREBBP are a cause of Rubinstein-Taybi syndrome type 1 (RSTS1) [MIM:[http://omim.org/entry/180849 180849]]. RSTS1 is an autosomal dominant disorder characterized by craniofacial abnormalities, broad thumbs, broad big toes, mental retardation and a propensity for development of malignancies.<ref>PMID:11331617</ref> <ref>PMID:12114483</ref> <ref>PMID:12566391</ref> <ref>PMID:15706485</ref>
-
 
+
== Function ==
-
==Function==
+
[[http://www.uniprot.org/uniprot/CBP_HUMAN CBP_HUMAN]] Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1 in the presence of EP300.<ref>PMID:9707565</ref> <ref>PMID:11154691</ref> <ref>PMID:12738767</ref> <ref>PMID:12929931</ref>
[[http://www.uniprot.org/uniprot/CBP_HUMAN CBP_HUMAN]] Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1 in the presence of EP300.<ref>PMID:9707565</ref> <ref>PMID:11154691</ref> <ref>PMID:12738767</ref> <ref>PMID:12929931</ref>
-
==About this Structure==
+
==See Also==
-
[[4nyv]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NYV OCA].
+
*[[CREB-binding protein|CREB-binding protein]]
-
 
+
== References ==
-
==Reference==
+
<references/>
-
<references group="xtra"/><references/>
+
__TOC__
-
[[Category: Arrowsmith, C H.]]
+
</StructureSection>
-
[[Category: Bountra, C.]]
+
[[Category: Human]]
-
[[Category: Brennan, P.]]
+
[[Category: Arrowsmith, C H]]
-
[[Category: Delft, F Von.]]
+
[[Category: Bountra, C]]
-
[[Category: Edwards, A M.]]
+
[[Category: Brennan, P]]
-
[[Category: Fedorov, O.]]
+
[[Category: Delft, F Von]]
-
[[Category: Felletar, I.]]
+
[[Category: Edwards, A M]]
-
[[Category: Filippakopoulos, P.]]
+
[[Category: Fedorov, O]]
-
[[Category: Knapp, S.]]
+
[[Category: Felletar, I]]
-
[[Category: Martin, S.]]
+
[[Category: Filippakopoulos, P]]
-
[[Category: Monteiro, O P.]]
+
[[Category: Knapp, S]]
-
[[Category: Picaud, S.]]
+
[[Category: Martin, S]]
-
[[Category: SGC, Structural Genomics Consortium.]]
+
[[Category: Monteiro, O P]]
 +
[[Category: Picaud, S]]
 +
[[Category: Structural genomic]]
[[Category: Bromodomain]]
[[Category: Bromodomain]]
[[Category: Creb binding]]
[[Category: Creb binding]]
[[Category: Crebbp]]
[[Category: Crebbp]]
[[Category: Kat3a]]
[[Category: Kat3a]]
-
[[Category: Rst]]
 
[[Category: Rst]]
[[Category: Rst]]
[[Category: Sgc]]
[[Category: Sgc]]
-
[[Category: Structural genomics consortium]]
 
[[Category: Transcription]]
[[Category: Transcription]]

Revision as of 09:15, 15 February 2015

Crystal Structure of the Bromodomain of human CREBBP in complex with a quinazolin-one ligand

4nyv, resolution 1.83Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4nyv"
Personal tools