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3wq9
From Proteopedia
(Difference between revisions)
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| - | + | ==Crystal structure of Hsp90-alpha N-terminal domain in complex with 2-(4-Hydroxy-cyclohexylamino)-4-[5-(4-phenyl-imidazol-1-yl)-isoquinolin-1-yl]-benzamide== | |
| - | + | <StructureSection load='3wq9' size='340' side='right' caption='[[3wq9]], [[Resolution|resolution]] 1.80Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[3wq9]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WQ9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3WQ9 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=YUK:2-[(TRANS-4-HYDROXYCYCLOHEXYL)AMINO]-4-[5-(4-PHENYL-1H-IMIDAZOL-1-YL)ISOQUINOLIN-1-YL]BENZAMIDE'>YUK</scene></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3wq9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wq9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3wq9 RCSB], [http://www.ebi.ac.uk/pdbsum/3wq9 PDBsum]</span></td></tr> | |
| - | + | </table> | |
| - | [[Category: | + | == Function == |
| + | [[http://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN]] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Chong, K T]] | ||
| + | [[Category: Kitade, M]] | ||
| + | [[Category: Oshiumi, H]] | ||
[[Category: Uno, T]] | [[Category: Uno, T]] | ||
[[Category: Yamashita, S]] | [[Category: Yamashita, S]] | ||
| - | [[Category: | + | [[Category: Atp binding]] |
| - | [[Category: | + | [[Category: Chaperone]] |
| - | [[Category: | + | [[Category: Hydrolase]] |
Revision as of 14:00, 25 February 2015
Crystal structure of Hsp90-alpha N-terminal domain in complex with 2-(4-Hydroxy-cyclohexylamino)-4-[5-(4-phenyl-imidazol-1-yl)-isoquinolin-1-yl]-benzamide
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Categories: Chong, K T | Kitade, M | Oshiumi, H | Uno, T | Yamashita, S | Atp binding | Chaperone | Hydrolase
