Beta-lactamase

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Line 10: Line 10:
*'''β-lactamase class A'''
*'''β-lactamase class A'''
-
**[[3dtm]], [[1bza]], [[1ck3]], [[1esu]], [[1jwp]], [[1lhy]], [[1li0]], [[1m40]], [[1zg6]], [[2v1z]], [[2v20]], [[3cmz]], [[3jyi]], [[4ibr]], [[4ibx]] - EcBlac A Tem-1 (mutant) - ''Escherichia coli''<br />
+
**[[3dtm]], [[1bza]], [[1ck3]], [[1esu]], [[1jwp]], [[1lhy]], [[1li0]], [[1m40]], [[1zg6]], [[2v1z]], [[2v20]], [[3cmz]], [[3jyi]], [[4ibr]], [[4ibx]], [[4mez]], [[4rx2]], [[4rx3]] - EcBlac A Tem-1 (mutant) - ''Escherichia coli''<br />
-
**[[1btl]], [[1iys]], [[1xpb]], [[1zg4]], [[4gku]] - EcBlac A Tem-1<br />
+
**[[1btl]], [[1iys]], [[1xpb]], [[1zg4]], [[4gku]], [[4rva]] - EcBlac A Tem-1<br />
**[[1lhy]] - EcBlac A Tem-30 (mutant) <br />
**[[1lhy]] - EcBlac A Tem-30 (mutant) <br />
**[[1li0]] - EcBlac A Tem-32 (mutant) <br />
**[[1li0]] - EcBlac A Tem-32 (mutant) <br />
Line 18: Line 18:
**[[3toi]] - EcBlac A Tem-116 (mutant)<br />
**[[3toi]] - EcBlac A Tem-116 (mutant)<br />
**[[4id4]] – EcBlac/PaBlac Tem<br />
**[[4id4]] – EcBlac/PaBlac Tem<br />
-
**[[1we4]], [[2xr0]], [[2zq7]], [[2zq8]], [[2zq9]], [[2zqa]], [[2zqc]], [[2zqd]], [[4bd0]], [[4bd1]] - EcBlac A Toho-1 (mutant) <br />
+
**[[1we4]], [[2xr0]], [[2zq7]], [[2zq8]], [[2zq9]], [[2zqa]], [[2zqc]], [[2zqd]], [[4bd0]], [[4bd1]], [[4c3k]] - EcBlac A Toho-1 (mutant) <br />
**[[2xqz]], [[2wyx]] - EcBlac A Toho-1 (mutant) – Neutron<br />
**[[2xqz]], [[2wyx]] - EcBlac A Toho-1 (mutant) – Neutron<br />
**[[3c5a]] – EcBlac A Kpc-2<br />
**[[3c5a]] – EcBlac A Kpc-2<br />
Line 34: Line 34:
**[[1kge]], [[1kgf]], [[1kgg]], [[1ome]] – SaBlac A (mutant) - S''taphylococcus aureus''<br />
**[[1kge]], [[1kgf]], [[1kgg]], [[1ome]] – SaBlac A (mutant) - S''taphylococcus aureus''<br />
**[[3blm]] – SaBlac A<br />
**[[3blm]] – SaBlac A<br />
-
**[[1mbl]], [[3ly3]], [[3soi]] – BlBlac A (mutant) – ''Bacillus licheniformis''<br />
+
**[[1mbl]], [[3ly3]], [[3soi]], [[4n92]] – BlBlac A (mutant) – ''Bacillus licheniformis''<br />
**[[2blm]], [[3sh7]], [[4blm]] – BlBlac A<br />
**[[2blm]], [[3sh7]], [[4blm]] – BlBlac A<br />
**[[2cc1]] – Blac A – ''Mycobacterium fortuitum''<br />
**[[2cc1]] – Blac A – ''Mycobacterium fortuitum''<br />
Line 40: Line 40:
**[[3s4x]] - EncBlac A (mutant) – ''Enterobacter cloacae''<br />
**[[3s4x]] - EncBlac A (mutant) – ''Enterobacter cloacae''<br />
**[[3zdj]], [[4b88]] – Blac – precambrian<br />
**[[3zdj]], [[4b88]] – Blac – precambrian<br />
 +
**[[4c6y]], [[4c75]] – Blac – synthetic<br />
*Extended-spectrum β-lactamase class A
*Extended-spectrum β-lactamase class A
Line 45: Line 46:
**[[4gog]] - PaESBL A GES-1 + acyl intermediate<br />
**[[4gog]] - PaESBL A GES-1 + acyl intermediate<br />
**[[3nia]] - PaESBL A GES-2 + inhibitor<br />
**[[3nia]] - PaESBL A GES-2 + inhibitor<br />
 +
**[[4qu3]] - PaESBL A GES-2 + antibiotic<br />
**[[4gnu]], [[4h8r]] - PaESBL A GES-5<br />
**[[4gnu]], [[4h8r]] - PaESBL A GES-5<br />
**[[3v3s]] – PaESBL GES-18<br />
**[[3v3s]] – PaESBL GES-18<br />
**[[1e25]] – PaESBL PER-1 (mutant)<br />
**[[1e25]] – PaESBL PER-1 (mutant)<br />
-
**[[3znw]] - CfESBL PER-2 + antribiotic – ''Citrobacter freundii''<br />
+
**[[4mx4]], [[4mxg]] – PaESBL Bel-1 <br />
 +
**[[4mxb]], [[4mxh]] – PaESBL Bel-1 + antibiotic<br />
 +
**[[4d2o]] - CfESBL PER-2 – ''Citrobacter freundii''<br />
 +
**[[3znw]] - CfESBL PER-2 + antribiotic <br />
**[[3v3r]] - AbESBL A GES-11– ''Acinetobacter baumannii''<br />
**[[3v3r]] - AbESBL A GES-11– ''Acinetobacter baumannii''<br />
**[[3tsg]] – AbESBL GES-14<br />
**[[3tsg]] – AbESBL GES-14<br />
Line 54: Line 59:
**[[3ni9]] - PaESBL A GES-2<br />
**[[3ni9]] - PaESBL A GES-2<br />
**[[3g2y]], [[3g2z]], [[3g30]], [[3g31]], [[3g32]], [[3g34]], [[3g35]], [[4dds]], [[4ddy]], [[4de0]], [[4de1]], [[4de2]], [[4de3]] - EcBlac A Ctx-M-9 + inhibitor<br />
**[[3g2y]], [[3g2z]], [[3g30]], [[3g31]], [[3g32]], [[3g34]], [[3g35]], [[4dds]], [[4ddy]], [[4de0]], [[4de1]], [[4de2]], [[4de3]] - EcBlac A Ctx-M-9 + inhibitor<br />
 +
**[[4len]] - EcBlac A Ctx-M-9 (mutant) + inhibitor<br />
**[[3hlw]], [[3huo]], [[3hvf]] - EcBlac A Ctx-M-9 (mutant) + antibiotic<br />
**[[3hlw]], [[3huo]], [[3hvf]] - EcBlac A Ctx-M-9 (mutant) + antibiotic<br />
 +
**[[4pm8]] - KpBlac A Ctx-M-14 <br />
 +
**[[4pm6]], [[4pma]] - KpBlac A Ctx-M-14 (mutant) <br />
 +
**[[4pm9]] - KpBlac A Ctx-M-14 + antibiotic<br />
 +
**[[4pm5]], [[4pm7]] - KpBlac A Ctx-M-14 (mutant) + antibiotic<br />
 +
**[[4s2i]] - KpBlac A Ctx-M-15 + antibiotic<br /
**[[4hbt]] – EcESBL Ctx-M-15<br />
**[[4hbt]] – EcESBL Ctx-M-15<br />
**[[4hbu]] – EcESBL Ctx-M-15 + inhibitor<br />
**[[4hbu]] – EcESBL Ctx-M-15 + inhibitor<br />
Line 66: Line 77:
**[[1erm]], [[1ero]], [[1erq]] – EcBlac A Tem-1 + boronic acid inhibitor<br />
**[[1erm]], [[1ero]], [[1erq]] – EcBlac A Tem-1 + boronic acid inhibitor<br />
**[[1jwv]], [[1jwz]] - EcBlac A Tem-1 (mutant) + boronic acid inhibitor<br />
**[[1jwv]], [[1jwz]] - EcBlac A Tem-1 (mutant) + boronic acid inhibitor<br />
-
**[[1ong]], [[1q2p]], [[1vm1]], [[2h5s]], [[2zd8]], [[3d4f]], [[3mke]], [[3mkf]], [[3mxr]], [[3mxs]], [[4fh2]], [[4gd6]], [[4gd8]], [[4gdb]] - KpBlac A Shv-1 + inhibitor<br />
+
**[[1ong]], [[1q2p]], [[1vm1]], [[2h5s]], [[2zd8]], [[3d4f]], [[3mke]], [[3mkf]], [[3mxr]], [[3mxs]], [[4fh2]], [[4gd6]], [[4gd8]], [[4gdb]], [[4mbf]], [[4r3b]] - KpBlac A Shv-1 + inhibitor<br />
-
**[[1rcj]], [[1tdg]], [[2a49]], [[2h0t]], [[2h0y]], [[2h10]] - KpBlac A Shv-1 (mutant) + inhibitor<br />
+
**[[1rcj]], [[1tdg]], [[2a49]], [[2h0t]], [[2h0y]], [[2h10]], [[4mbh]], [[4mbk]] - KpBlac A Shv-1 (mutant) + inhibitor<br />
**[[3opp]], [[3opr]]- KpBlac A Shv-1 (mutant) + antibiotic<br />
**[[3opp]], [[3opr]]- KpBlac A Shv-1 (mutant) + antibiotic<br />
**[[1w7f]], [[3b3x]], [[2y91]], [[4a5r]] - BlBlac A + inhibitor<br />
**[[1w7f]], [[3b3x]], [[2y91]], [[4a5r]] - BlBlac A + inhibitor<br />
-
**[[3m2j]] - BlBlac A (mutant) + inhibitor<br />
+
**[[3m2j]], [[4n9k]], [[4n9l]] - BlBlac A (mutant) + inhibitor<br />
**[[2wk0]], [[2x71]]– BlBlac A + antibiotic<br />
**[[2wk0]], [[2x71]]– BlBlac A + antibiotic<br />
**[[3ly4]], [[3m2k]], [[3sh8]], [[3sh9]] - BlBlac A (mutant) + antibiotic<br />
**[[3ly4]], [[3m2k]], [[3sh8]], [[3sh9]] - BlBlac A (mutant) + antibiotic<br />
 +
**[[4m3k]], [[4n1h]] - BlBlac A + antibody<br />
**[[2q9m]], [[2q9n]] - EncBlac A + inhibitor <br />
**[[2q9m]], [[2q9n]] - EncBlac A + inhibitor <br />
**[[3bfc]], [[3bff]], [[3bfg]] – CsBlac A Sed-1 (mutant) + inhibitor<br />
**[[3bfc]], [[3bff]], [[3bfg]] – CsBlac A Sed-1 (mutant) + inhibitor<br />
Line 91: Line 103:
*'''β-lactamase class B (Zn containing)'''
*'''β-lactamase class B (Zn containing)'''
-
**[[3fcz]], [[3i0v]], [[3i11]], [[3i13]], [[3i14]], [[3i15]], [[1bc2]], [[1bvt]], [[1mqo]], [[2bc2]], [[3bc2]], [[1bmc]] – BcBlac B - ''Bacillus cereus''<br />
+
**[[3fcz]], [[3i0v]], [[3i11]], [[3i13]], [[3i14]], [[3i15]], [[1bc2]], [[1bvt]], [[1mqo]], [[2bc2]], [[3bc2]], [[1bmc]], [[4c09]], [[4nq4]] – BcBlac B - ''Bacillus cereus''<br />
**[[2m5c]] - BcBlac B – NMR<br />
**[[2m5c]] - BcBlac B – NMR<br />
**[[3knr]], [[3kns]], [[1dxk]], [[2bfk]], [[2bfl]], [[2bfz]], [[2bg2]], [[2bg6]], [[2bg7]], [[2bg8]], [[2bga]], [[2nxa]], [[2nyp]], [[2nze]], [[2nzf]], [[2uyx]] - BcBlac B (mutant) <br />
**[[3knr]], [[3kns]], [[1dxk]], [[2bfk]], [[2bfl]], [[2bfz]], [[2bg2]], [[2bg6]], [[2bg7]], [[2bg8]], [[2bga]], [[2nxa]], [[2nyp]], [[2nze]], [[2nzf]], [[2uyx]] - BcBlac B (mutant) <br />
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**[[1k07]] – FgBlac B - ''Fluoribacter gormanii''<br />
**[[1k07]] – FgBlac B - ''Fluoribacter gormanii''<br />
**[[1l9y]] - FgBlac B (mutant) <br />
**[[1l9y]] - FgBlac B (mutant) <br />
-
**[[1ko2]], [[1ko3]] – PaBlac B Vim-2 - ''Pseudomonas aeruginosa''<br />
+
**[[1ko2]], [[1ko3]], [[4bz3]], [[4nq2]] – PaBlac B Vim-2 - ''Pseudomonas aeruginosa''<br />
**[[2whg]], [[2wrs]] - PaBlac B Vim-4<br />
**[[2whg]], [[2wrs]] - PaBlac B Vim-4<br />
 +
**[[4d1t]] - PaBlac B Vim-7<br />
 +
**[[4d1u]], [[4d1v]], [[4d1w]] - PaBlac B Vim-7 (mutant)<br />
**[[4awy]], [[4awz]] - PaBlac B Aim-1<br />
**[[4awy]], [[4awz]] - PaBlac B Aim-1<br />
 +
**[[2ynt]], [[2ynu]], [[2ynv]], [[2ynw]] - PaBlac B Gim-1<br />
**[[4ax0]], [[4ax1]] - PaBlac B Aim-1 (mutant)<br />
**[[4ax0]], [[4ax1]] - PaBlac B Aim-1 (mutant)<br />
**[[2y87]], [[2y8a]], [[2y8b]] - PaBlac B Vim-7<br />
**[[2y87]], [[2y8a]], [[2y8b]] - PaBlac B Vim-7<br />
-
**[[2fhx]] - PaBlac B Spm-1<br />
+
**[[2fhx]], [[4bp0]] - PaBlac B Spm-1<br />
**[[2x01]] - PaBlac Oxa-10 (mutant)<br />
**[[2x01]] - PaBlac Oxa-10 (mutant)<br />
**[[2x02]] - PaBlac Oxa-10<br />
**[[2x02]] - PaBlac Oxa-10<br />
 +
**[[4uam]] - PaBlac Imp-1 <br />
**[[4f6h]], [[4f6z]] – PaBlac Imp-1 (mutant)<br />
**[[4f6h]], [[4f6z]] – PaBlac Imp-1 (mutant)<br />
**[[1wuo]], [[1wup]] - SmBlac Imp-1 (mutant) – ''Serratia marcescens''<br />
**[[1wuo]], [[1wup]] - SmBlac Imp-1 (mutant) – ''Serratia marcescens''<br />
Line 126: Line 142:
**[[2yz3]] – Blac Vim-2 – ''Pseudomonas putida''<br />
**[[2yz3]] – Blac Vim-2 – ''Pseudomonas putida''<br />
**[[3sd9]] – SfBlac B - ''Serratia fonticola''<br />
**[[3sd9]] – SfBlac B - ''Serratia fonticola''<br />
-
**[[3pg4]] – KpBlac Ndm-1
+
**[[4ubq]] - AbBlac Imp-2 <br />
 +
**[[3pg4]] – KpBlac Ndm-1<br />
 +
**[[4uwo]], [[4uwp]], [[4uwr]], [[4uws]] - KpBlac B Vim-26<br />
 +
**[[4wd6]] – Blac Dim-1 – ''Pseudomonas stutzeri''<br />
*β-lactamase class B binary complex
*β-lactamase class B binary complex
Line 132: Line 151:
**[[1a8t]], [[1hlk]], [[1kr3]] - BfBlac B + inhibitor<br />
**[[1a8t]], [[1hlk]], [[1kr3]] - BfBlac B + inhibitor<br />
**[[1jt1]] – FgBlac + captopril <br />
**[[1jt1]] – FgBlac + captopril <br />
-
**[[1jje]], [[1jjt]], [[3lce]] - PaBlac B + inhibitor<br />
+
**[[1jje]], [[1jjt]], [[3lce]], [[3wxc]], [[4c1f]], [[4c1g]] - PaBlac B Imp-1+ inhibitor<br />
 +
**[[4c1d]], [[4c1e]], [[4pvo]], [[4pvt]], [[4ua4]] - PaBlac B Vim-2 + inhibitor<br />
 +
**[[4s2o]] - PaBlac Oxa-10 + antibiotic<br />
**[[1m2x]] – Blac B + captopril – ''Elizabethkingia meningoseptica''<br />
**[[1m2x]] – Blac B + captopril – ''Elizabethkingia meningoseptica''<br />
**[[1vgn]], [[3vqz]] - SmBlac Imp-1+ inhibitor<br />
**[[1vgn]], [[3vqz]] - SmBlac Imp-1+ inhibitor<br />
Line 142: Line 163:
**[[2qds]] – AhBlac B + captopril<br />
**[[2qds]] – AhBlac B + captopril<br />
**[[3m8t]] – BjBlac B + inhibitor<br />
**[[3m8t]] – BjBlac B + inhibitor<br />
-
**[[2m5d]] - BcBlac B + inhibitor<br />
+
**[[2m5d]], [[4c1c]], [[4c1h]], [[4nq5]], [[4nq6]], [[4nq7]], [[4tyt]] - BcBlac B + inhibitor<br />
**[[3q6v]] – SfBlac B + glycerol <br />
**[[3q6v]] – SfBlac B + glycerol <br />
**[[3q6x]], [[4ey2]], [[4eyb]], [[4eyf]], [[4efl]], [[4hl1]], [[4hl2]] – KpBlac B Ndm-1+ antibiotic<br />
**[[3q6x]], [[4ey2]], [[4eyb]], [[4eyf]], [[4efl]], [[4hl1]], [[4hl2]] – KpBlac B Ndm-1+ antibiotic<br />
-
**[[4exy]], [[4exs]], [[4eyl]], [[4hky]] – KpBlac B Ndm-1+ inhibitor
+
**[[4exy]], [[4exs]], [[4eyl]], [[4hky]], [[4ram]], [[4raw]], [[4rbs]], [[4rl0]], [[4rl2]], [[4u4l]] – KpBlac B Ndm-1+ inhibitor<br />
 +
**[[4rm5]] – KpBlac B Ndm-1 (mutant) + antibiotic<br />
*'''β-lactamase class C'''
*'''β-lactamase class C'''
Line 151: Line 173:
**[[3fkw]], [[3iwi]], [[3iwo]], [[3iwq]], [[3ixd]] – EcBlac C (mutant) <br />
**[[3fkw]], [[3iwi]], [[3iwo]], [[3iwq]], [[3ixd]] – EcBlac C (mutant) <br />
**[[1zkj]] – Blac C – ''Enterobacter aerogenes''<br />
**[[1zkj]] – Blac C – ''Enterobacter aerogenes''<br />
-
**[[2qz6]] – Blac C – ''Pseudomonas fluorescens''
+
**[[2qz6]] – Blac C – ''Pseudomonas fluorescens''<br />
 +
**[[3w8k]] – KpBlac C<br />
 +
**[[4u0t]] – AbBlac C Adc-7<br />
 +
**[[4qd4]] – AbBlac C Adc-68<br />
*β-lactamase class C binary complex
*β-lactamase class C binary complex
Line 161: Line 186:
**[[1onh]], [[1q2q]], [[1y54]] - EncBlac C + inhibitor<br />
**[[1onh]], [[1q2q]], [[1y54]] - EncBlac C + inhibitor<br />
**[[1s6r]] - EncBlac C+ boronic acid inhibitor<br />
**[[1s6r]] - EncBlac C+ boronic acid inhibitor<br />
-
**[[1rgz]] - EncBlac C + antribiotic<br />
+
**[[1rgz]] - EncBlac C + antibiotic<br />
**[1rgy]] - CfBlac C + antibiotic <br />
**[1rgy]] - CfBlac C + antibiotic <br />
**[[1zc2]], [[2zc7]] – KpBlac C + inhibitor<br />
**[[1zc2]], [[2zc7]] – KpBlac C + inhibitor<br />
**[[2wzx]], [[2wzz]] – PaBlac C + inhibitor<br />
**[[2wzx]], [[2wzz]] – PaBlac C + inhibitor<br />
 +
**[[4ooy]] - PaBlac C + antibiotic<br />
 +
**[[4u0x]] - AbBlac C Adc-7 + boronic acid inhibitor <br />
*'''β-lactamase class D'''
*'''β-lactamase class D'''
Line 178: Line 205:
**[[4mll]] - KpBlac D Oxa-1 + oxacillin<br />
**[[4mll]] - KpBlac D Oxa-1 + oxacillin<br />
**[[3hbr]] – KpBlac D Oxa-48<br />
**[[3hbr]] – KpBlac D Oxa-48<br />
-
**[[3if6]] - KpBlac D Oxa-46<br />
+
**[[4s2j]], [[4s2k]], [[4s2n]], [[4wmc]] - KpBlac D Oxa-48 + antibiotic<br />
 +
**[[3if6]], [[4s2p]] - KpBlac D Oxa-46<br />
**[[4ied]] – Blac – ''Fusobacterium nucleatum''<br />
**[[4ied]] – Blac – ''Fusobacterium nucleatum''<br />
Line 194: Line 222:
**[[1ke4]], [[2bls]], [[2zj9]], [[3bls]] – EcBlac<br />
**[[1ke4]], [[2bls]], [[2zj9]], [[3bls]] – EcBlac<br />
-
**[[1l0d]], [[1l0e]], [[1l0f]], [[1l0g]] - EcBlac (mutant)
+
**[[1l0d]], [[1l0e]], [[1l0f]], [[1l0g]], [[4kg6]] - EcBlac (mutant)
**[[1fcn]] – EcBlac (mutant) + substrate<br />
**[[1fcn]] – EcBlac (mutant) + substrate<br />
-
**[[1fco]], [[1i5q]], [[1kvl]] - EcBlac (mutant) + antibiotic<br />
+
**[[1fco]], [[1i5q]], [[1kvl]], [[4ken]], [[4kg2]], [[4kg5]], [[4kg6]], [[4kz3]], [[4kz4]], [[4kg9]], [[4kz5]], [[4kz6]], [[4kz7]], [[4kz8]], [[4kza]], [[4kzb]] - EcBlac (mutant) + antibiotic<br />
-
**[[1iel]], [[1fcm]], [[1iem]], [[1kvm]], [[1ll5]], [[1ll9]], [[1llb]] - EcBlac + antibiotic<br />
+
**[[1iel]], [[1fcm]], [[1iem]], [[1kvm]], [[1ll5]], [[1ll9]], [[1llb]], [[4kz3]], [[4kz4]], [[4okp]], [[4olg]] - EcBlac + antibiotic<br />
-
**[[1fsw]], [[1fsy]], [[1kds]], [[1kdw]], [[1ke0]], [[1ke3]], [[1mxo]], [[1my8]], [[4e3i]], [[4e3j]], [[4e3k]], [[4e3l]], [[4e3m]], [[4e3n]], [[4e3o]], [[2i72]] - EcBlac + boronic acid inhibitor<br />
+
**[[1fsw]], [[1fsy]], [[1kds]], [[1kdw]], [[1ke0]], [[1ke3]], [[1mxo]], [[1my8]], [[4e3i]], [[4e3j]], [[4e3k]], [[4e3l]], [[4e3m]], [[4e3n]], [[4e3o]], [[2i72]], [[4lv0]], [[4lv1]], [[4lv2]], [[4lv3]] - EcBlac + boronic acid inhibitor<br />
**[[1pi4]], [[1pi5]], [[2ffy]] - EcBlac (mutant) + boronic acid inhibitor<br />
**[[1pi4]], [[1pi5]], [[2ffy]] - EcBlac (mutant) + boronic acid inhibitor<br />
-
**[[1l2s]], [[1xgi]], [[1xgj]], [[2hdq]], [[2hdr]], [[2hds]], [[2hdu]], [[2p9v]], [[2pu2]], [[2pu4]], [[2r9w]], [[2r9x]], [[2rcx]] - EcBlac + inhibitor<br />
+
**[[1l2s]], [[1xgi]], [[1xgj]], [[2hdq]], [[2hdr]], [[2hds]], [[2hdu]], [[2p9v]], [[2pu2]], [[2pu4]], [[2r9w]], [[2r9x]], [[2rcx]], [[4jxs]], [[4jxv]], [[4jxw]], [[4old]] - EcBlac + inhibitor<br />
 +
**[[4jxg]] – EcBlac + oxacillin<br />
**[[1o07]] - EcBlac (mutant) + inhibitor<br />
**[[1o07]] - EcBlac (mutant) + inhibitor<br />
**[[3s1y]], [[3s22]] - PaBlac (mutant) + inhibitor<br />
**[[3s1y]], [[3s22]] - PaBlac (mutant) + inhibitor<br />
-
**[[4hef]] - PaBlac + inhibitor<br />
+
**[[4hef]], [[4nk3]] - PaBlac + inhibitor<br />
**[[4gzb]] – PaBlac<br />
**[[4gzb]] – PaBlac<br />
 +
**[[4net]] – AbBlac<br />
*'''Carbapenemase'''
*'''Carbapenemase'''
Line 216: Line 246:
**[[4jf5]], [[4jf6]] - AbBlac OXA-23 <br />
**[[4jf5]], [[4jf6]] - AbBlac OXA-23 <br />
**[[4jf4]] - AbBlac OXA-23 + antibiotic<br />
**[[4jf4]] - AbBlac OXA-23 + antibiotic<br />
 +
**[[4oh0]] - AbBlac OXA-58 <br />
**[[1bue]] – EncBlac<br />
**[[1bue]] – EncBlac<br />
Line 228: Line 259:
**[[1i2s]] – BlBlac<br />
**[[1i2s]] – BlBlac<br />
**[[2gdn]], [[3zhh]] – MtBlac – ''Mycobacterium tuberculosis''<br />
**[[2gdn]], [[3zhh]] – MtBlac – ''Mycobacterium tuberculosis''<br />
 +
**[[4whi]] – MtBlac C terminal<br />
**[[4jlf]] - MtBlac (mutant)<br />
**[[4jlf]] - MtBlac (mutant)<br />
**[[3vff]], [[3vfh]], [[4ebl]], [[4ebn]], [[4ebp]] – MtBlac (mutant) + intermediate<br />
**[[3vff]], [[3vfh]], [[4ebl]], [[4ebn]], [[4ebp]] – MtBlac (mutant) + intermediate<br />
**[[4df6]] – MtBlac + inhibitor<br />
**[[4df6]] – MtBlac + inhibitor<br />
 +
**[[4q8i]], [[4qb8]] – MtBlac + antibiotic<br />
**[[2jc7]], [[3g4p]] – AbBlac <br />
**[[2jc7]], [[3g4p]] – AbBlac <br />
**[[3byd]] – Blac – ''Klebsiella oxytoca''<br />
**[[3byd]] – Blac – ''Klebsiella oxytoca''<br />
Line 242: Line 275:
**[[4k0w]] – AbBlac Oxa-23 (mutant)<br />
**[[4k0w]] – AbBlac Oxa-23 (mutant)<br />
**[[4k0x]] – AbBlac Oxa-23 <br />
**[[4k0x]] – AbBlac Oxa-23 <br />
 +
**[[3wrt]] – ChBlac – ''Chromohalobacter''<br />
 +
**[[3wrz]], [[3ws0]], [[3ws1]], [[3ws2]], [[3ws3]], [[3ws4]], [[3ws5]] – ChBlac (mutant)<br />
*Other β-lactamase binary complex
*Other β-lactamase binary complex
Line 255: Line 290:
**[[3dwz]], [[3iqa]], [[3m6b]], [[3m6h]] – MtBlac + inhibitor<br />
**[[3dwz]], [[3iqa]], [[3m6b]], [[3m6h]] – MtBlac + inhibitor<br />
**[[3fv7]], [[3fyz]], [[3fzc]], [[3mbz]] – AbBlac + inhibitor<br />
**[[3fv7]], [[3fyz]], [[3fzc]], [[3mbz]] – AbBlac + inhibitor<br />
 +
**[[4wm9]] – AbBlac Oxa-24 + antibiotic <br />
}}
}}

Revision as of 07:56, 8 March 2015

Template:STRUCTURE 3bm6

Beta-lactamase (Blac) are enzymes which make bacteria resistant to β-lactam antibiotics by breaking their β-lactam ring. Blac are classified according to their resistance targets. Class C are cephalosporinases; Class A are broad-spectrum; Class B are metalloenzymes; Class D are cloxacilanases. Carbapenemase (Car) are Blac with wide hydrolytic capacities. Car can hydrolyze penicillins, cephalosporins, monobactams and carbapenems. Extended-spectrum Blac class A (ESBL) hydrolyze penicillins but not cephalosporins.

3D Structures of Beta-lactamase

Updated on 08-March-2015

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Jaime Prilusky, Alexander Berchansky, Joel L. Sussman

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