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Cathepsin
From Proteopedia
(Difference between revisions)
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
{{#tree:id=OrganizedByTopic|openlevels=0| | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
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| + | *Procathepsin-A (Lysosomal protective protein) | ||
| + | |||
| + | **[[4ci9]], [[1ivy]], [[4mws]], [[4mwt]] - hCTSB – human<br /> | ||
| + | **[[4cia]], [[4cib]] - hCTSB + inhibitor<br /> | ||
* Procathepsin-B | * Procathepsin-B | ||
| - | **[[1pbh]], [[2pbh]], [[3pbh]] – hPCTSB | + | **[[1pbh]], [[2pbh]], [[3pbh]] – hPCTSB <br /> |
**[[1mir]] - rPCTSB (mutant) - rat<br /> | **[[1mir]] - rPCTSB (mutant) - rat<br /> | ||
**[[4n4z]], [[4hwy]] - TbCTSB – ''Trypanosoma brucei''<br /> | **[[4n4z]], [[4hwy]] - TbCTSB – ''Trypanosoma brucei''<br /> | ||
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**[[1lyw]], [[1lya]] – hMCTSD <br /> | **[[1lyw]], [[1lya]] – hMCTSD <br /> | ||
**[[1lyb]] - hMCTSD+pepstatin<br /> | **[[1lyb]] - hMCTSD+pepstatin<br /> | ||
| + | **[[4obz]], [[4oc6]], [[4od9]] – hMCTSD + non-peptidic inhibitor<br /> | ||
* Cathepsin-E mature | * Cathepsin-E mature | ||
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* Cathepsin-K mature | * Cathepsin-K mature | ||
| + | **[[4n79]] – hMCTSK<br /> | ||
**[[3o1g]], [[3n3g]], [[2r6n]], [[1bgo]], [[3kwz]], [[3kx1]], [[3o0u]] – hMCTSK+ pyrimidine inhibitor<br /> | **[[3o1g]], [[3n3g]], [[2r6n]], [[1bgo]], [[3kwz]], [[3kx1]], [[3o0u]] – hMCTSK+ pyrimidine inhibitor<br /> | ||
**[[3mpe]], [[3mpf]] – hMCTSK (mutant) + pyrimidine inhibitor<br /> | **[[3mpe]], [[3mpf]] – hMCTSK (mutant) + pyrimidine inhibitor<br /> | ||
**[[3h7d]] - hMCTSK (mutant) + chondroitin-4-sulfate<br /> | **[[3h7d]] - hMCTSK (mutant) + chondroitin-4-sulfate<br /> | ||
| - | **[[3c9e]] - hMCTSK + chondroitin-4-sulfate<br /> | + | **[[3c9e]], [[4n8w]] - hMCTSK + chondroitin-4-sulfate<br /> |
**[[3kwb]] - hMCTSK (mutant)+dioxo-triazine<br /> | **[[3kwb]] - hMCTSK (mutant)+dioxo-triazine<br /> | ||
**[[3kw9]] - hMCTSK +triazine<br /> | **[[3kw9]] - hMCTSK +triazine<br /> | ||
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**[[2r9m]], [[2r9n]], [[2r9o]] – hMCTSS+piperidine inhibitor<br /> | **[[2r9m]], [[2r9n]], [[2r9o]] – hMCTSS+piperidine inhibitor<br /> | ||
**[[2op3]], [[2hhn]], [[2g7y]], [[2hh5]], [[2f1g]] – hMCTSS+aryl inhibitor<br /> | **[[2op3]], [[2hhn]], [[2g7y]], [[2hh5]], [[2f1g]] – hMCTSS+aryl inhibitor<br /> | ||
| - | **[[2fud]], [[2fra]], [[2frq]], [[2ft2]], [[1npz]], [[1nqc]] – hMCTSS+inhibitor<br /> | + | **[[2fud]], [[2fra]], [[2frq]], [[2ft2]], [[1npz]], [[1nqc]], [[4p6e]], [[4p6g]] – hMCTSS+inhibitor<br /> |
**[[2fye]], [[2g6d]] – hMCTSS (mutant)+inhibitor<br /> | **[[2fye]], [[2g6d]] – hMCTSS (mutant)+inhibitor<br /> | ||
**[[2fq9]], [[1ms6]] – hMCTSS +nitrile inhibitor<br /> | **[[2fq9]], [[1ms6]] – hMCTSS +nitrile inhibitor<br /> | ||
**[[1glo]] - hMCTSS (mutant)<br /> | **[[1glo]] - hMCTSS (mutant)<br /> | ||
| - | **[[4bs5]] - mMCTSS+ pyrrolidine inhibitor<br /> | + | **[[4bs5]], [[4mzo]], [[4mzs]] - mMCTSS+ pyrrolidine inhibitor<br /> |
**[[4bsq]] - mMCTSS+ morpholine inhibitor<br /> | **[[4bsq]] - mMCTSS+ morpholine inhibitor<br /> | ||
| + | **[[4bpv]], [[4bqv]], [[4bs6]] - mMCTSS +nitrile inhibitor<br /> | ||
* Procathepsin-X | * Procathepsin-X | ||
Revision as of 09:45, 12 March 2015
Cathepsin (CTS) is a protease which becomes activated at low pH. It is found in lysosomes. Members of the CTS group are denoted as CTSA, CTSB etc and cleave proteins at different peptide bonds. The CTSs are expressed as an inactive precursor pro-CTS (PCTS) which become active when a long residue prosegment is cleaved off producing the mature CTS (MCTS).
3D Structures of Cathepsin
Updated on 12-March-2015
