Cyclohydrolase

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Revision as of 11:36, 18 March 2015

Structure of GTP cyclohydrolase I pentamer complex with 8-oxo-GTP (stick model) and Zn+2 ion (grey) (PDB code 1wuq).

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Updated on 18-March-2015

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 •	'''IMP cyclohydrolase''' catalyzes the conversion of IMP to formido-phosphosibosyl imidazole carboxamide.  ICH is part of the purine biosynthesis<br />
 •	'''Methenyltetrahydromethanopterin cyclohydrolase''' catalyzes the conversion of methenyltetrahydromethanopterin to formyl-tetrahydromethanopterin.  MCH is part of the folate biosynthesis<br />
+*       '''Methylenetetrahydrofolate dehydrogenase/cyclohydrolase''' catalyzes the interconversion of 5,10-methylenetetrahydrofolate and 10-formyltetrahydrofolate in mitochondria of mammalian cells.
 == Disease ==
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 **[[1qlm]] – MCH – ''Methanopyrus kandleri''<br />
+**[[4fio]] – MCH – ''Methanobrevibacter ruminatium''<br />
 **[[4gvr]] – AfMCH – ''Archaeoglobus fulgidus''<br />
 **[[4gvq]] – AfMCH + tetrahydromethanopterin <br />
 **[[4gvs]] – AfMCH + N5-formyl-tetrahydromethanopterin <br />
+* Methylenetetrahydrofolate dehydrogenase/cyclohydrolase
+**[[2c2x]], [[2c2y]] – MCH – ''Mycobacterium tuberculosis''<br />
+**[[1a4i]] – hMCH + NADP <br />
+**[[1dig]], [[1dia]], [[1dib]], [[1dig]] – hMCH + NADP + inhibitor<br />
 *Phosphoribosyl-ATP cyclohydrolase