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| - | ==Neuronal calcium sensor-1 (NCS-1)from Rattus norvegicus complex with rhodopsin kinase peptide from Homo sapiens==
| + | #REDIRECT [[5afp]] This PDB entry is obsolete and replaced by 5afp |
| - | <StructureSection load='4uyc' size='340' side='right' caption='[[4uyc]], [[Resolution|resolution]] 2.30Å' scene=''>
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| - | == Structural highlights ==
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| - | <table><tr><td colspan='2'>[[4uyc]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UYC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UYC FirstGlance]. <br>
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| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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| - | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Rhodopsin_kinase Rhodopsin kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.14 2.7.11.14] </span></td></tr>
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| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uyc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uyc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4uyc RCSB], [http://www.ebi.ac.uk/pdbsum/4uyc PDBsum]</span></td></tr>
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| - | </table>
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| - | == Disease ==
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| - | [[http://www.uniprot.org/uniprot/RK_HUMAN RK_HUMAN]] Oguchi disease;Congenital stationary night blindness. The disease is caused by mutations affecting the gene represented in this entry.
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| - | == Function ==
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| - | [[http://www.uniprot.org/uniprot/NCS1_RAT NCS1_RAT]] Neuronal calcium sensor, regulator of G protein-coupled receptor phosphorylation in a calcium dependent manner. Directly regulates GRK1 (RHOK), but not GRK2 to GRK5. Can substitute for calmodulin. Stimulates PI4KB kinase activity. Involved in long-term synaptic plasticity through its interaction with PICK1. May also play a role in neuron differentiation through inhibition of the activity of N-type voltage-gated calcium channel.<ref>PMID:17502602</ref> [[http://www.uniprot.org/uniprot/RK_HUMAN RK_HUMAN]] Retina-specific kinase involved in the signal turnoff via phosphorylation of rhodopsin (RHO), the G protein- coupled receptor that initiates the phototransduction cascade. This rapid desensitization is essential for scotopic vision and permits rapid adaptation to changes in illumination.<ref>PMID:15946941</ref>
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| - | == References ==
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| - | <references/>
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| - | __TOC__
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| - | </StructureSection>
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| - | [[Category: Rhodopsin kinase]]
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| - | [[Category: Burgoyne, R]]
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| - | [[Category: Derrick, J P]]
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| - | [[Category: Karuppiah, V]]
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| - | [[Category: Lian, L Y]]
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| - | [[Category: Pandalaneni, S]]
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| - | [[Category: Saleem, M]]
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| - | [[Category: Ion-transport protein]]
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