2r3c
From Proteopedia
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| - | [[Image:2r3c.gif|left|200px]] | + | [[Image:2r3c.gif|left|200px]] |
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| - | '''Structure of the gp41 N-peptide in complex with the HIV entry inhibitor PIE1''' | + | {{Structure |
| + | |PDB= 2r3c |SIZE=350|CAPTION= <scene name='initialview01'>2r3c</scene>, resolution 1.730Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=YT3:YTTRIUM+(III)+ION'>YT3</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene> and <scene name='pdbligand=NH2:AMINO GROUP'>NH2</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''Structure of the gp41 N-peptide in complex with the HIV entry inhibitor PIE1''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2R3C is a [ | + | 2R3C is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R3C OCA]. |
==Reference== | ==Reference== | ||
| - | Potent D-peptide inhibitors of HIV-1 entry., Welch BD, VanDemark AP, Heroux A, Hill CP, Kay MS, Proc Natl Acad Sci U S A. 2007 Oct 23;104(43):16828-33. Epub 2007 Oct 17. PMID:[http:// | + | Potent D-peptide inhibitors of HIV-1 entry., Welch BD, VanDemark AP, Heroux A, Hill CP, Kay MS, Proc Natl Acad Sci U S A. 2007 Oct 23;104(43):16828-33. Epub 2007 Oct 17. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17942675 17942675] |
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Heroux, A.]] | [[Category: Heroux, A.]] | ||
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[[Category: viral protein]] | [[Category: viral protein]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:32:08 2008'' |
Revision as of 16:32, 20 March 2008
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| , resolution 1.730Å | |||||||
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| Ligands: | , , and | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Structure of the gp41 N-peptide in complex with the HIV entry inhibitor PIE1
Overview
During HIV-1 entry, the highly conserved gp41 N-trimer pocket region becomes transiently exposed and vulnerable to inhibition. Using mirror-image phage display and structure-assisted design, we have discovered protease-resistant D-amino acid peptides (D-peptides) that bind the N-trimer pocket with high affinity and potently inhibit viral entry. We also report high-resolution crystal structures of two of these D-peptides in complex with a pocket mimic that suggest sources of their high potency. A trimeric version of one of these peptides is the most potent pocket-specific entry inhibitor yet reported by three orders of magnitude (IC(50) = 250 pM). These results are the first demonstration that D-peptides can form specific and high-affinity interactions with natural protein targets and strengthen their promise as therapeutic agents. The D-peptides described here address limitations associated with current L-peptide entry inhibitors and are promising leads for the prevention and treatment of HIV/AIDS.
About this Structure
2R3C is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.
Reference
Potent D-peptide inhibitors of HIV-1 entry., Welch BD, VanDemark AP, Heroux A, Hill CP, Kay MS, Proc Natl Acad Sci U S A. 2007 Oct 23;104(43):16828-33. Epub 2007 Oct 17. PMID:17942675
Page seeded by OCA on Thu Mar 20 18:32:08 2008
Categories: Protein complex | Heroux, A. | Hill, C P. | Kay, M S. | VanDemark, A P. | Welch, B. | ACE | CL | NH2 | YT3 | Hiv | Inhibitor | Peptide | Pie | Viral entry | Viral protein
