DNA glycosylase

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Line 42: Line 42:
**[[1yuo]] - hADG catalytic domain (mutant) <BR />
**[[1yuo]] - hADG catalytic domain (mutant) <BR />
**[[1x51]] – hADG NUDIX domain - NMR<BR />
**[[1x51]] – hADG NUDIX domain - NMR<BR />
-
**[[3fsp]], [[3fsq]] – GsADG + DNA – ''Geobacillus stearothermophilus''<BR />
+
**[[1wef]], [[1weg]], [[1kg4]], [[1kg5]], [[1kg6]], [[1kg7]], [[1kqj]], [[1mun]] - EcADG catalytic domain (mutant) - ''Escherichia coli''<BR />
-
**[[3g0q]], [[1vrl]], [[1rrq]], [[1rrs]] - GsADG (mutant) + DNA – ''Bacillus stearothermophilus''<BR />
+
-
**[[1wef]], [[1weg]], [[1kg4]], [[1kg5]], [[1kg6]], [[1kg7]], [[1kqj]] - EcADG catalytic domain (mutant) - ''Escherichia coli''<BR />
+
**[[1kg2]], [[1kg3]], [[1muy]] - EcADG catalytic domain<BR />
**[[1kg2]], [[1kg3]], [[1muy]] - EcADG catalytic domain<BR />
**[[1mun]] - EcADG catalytic domain (mutant) <BR />
**[[1mun]] - EcADG catalytic domain (mutant) <BR />
-
**[[1wei]], [[1mud]] - EcADG catalytic domain (mutant) + adenine
+
 
 +
*Adenine DG complex
 +
 
 +
**[[1wei]], [[1mud]] - EcADG catalytic domain (mutant) + adenine<br />
 +
**[[3fsp]], [[3fsq]] – GsADG + DNA – ''Geobacillus stearothermophilus''<BR />
 +
**[[3g0q]], [[1vrl]], [[1rrq]], [[1rrs]] - GsADG (mutant) + DNA <BR />
*Uracil DG
*Uracil DG
**[[3a7n]] – MtUDG – ''Mycobacterium tuberculosis''<BR />
**[[3a7n]] – MtUDG – ''Mycobacterium tuberculosis''<BR />
 +
**[[3tr7]] – UDG – ''Coxiella burnetii''<br />
 +
**[[1akz]], [[3tkb]] - hUDG (mutant) <BR />
 +
**[[2jhq]] – UDG – ''Vibrio cholerae''<BR />
 +
**[[2owq]], [[2owr]], [[3nt7]], [[4dof]], [[4dog]], [[4rib]], [[4lzb]] – UDG (mutant) – Vaccinia virus<BR />
 +
**[[2d3y]], [[1ui0]], [[1ui1]] – TtUDG – ''Thermus thermophilus''<BR />
 +
**[[1lqj]] – EcUDG<BR />
 +
**[[1flz]] - EcUDG (mutant) <BR />
 +
**[[1udh]], [[1udg]] – HsUDG - Herpes simplex virus<BR />
 +
**[[2c2p]], [[2boo]] – DrUDG – ''Deinococcus radiodurans''<BR />
 +
**[[2c2q]] – DrUDG (mutant) <BR />
 +
**[[1vk2]], [[1l9g]] – TmUDG - ''Thermotoga maritima''<BR />
 +
**[[1okb]] – AcUDG catalytic domain – Atlantic cod<br />
 +
**[[3wdf]] – SaUDG - ''Staphylococcus aureus''<br />
 +
**[[3zor]] – BsUDG – ''Bacillus subtilis''<br />
 +
 +
*Uracil DG complex
 +
**[[2zhx]] – MtDG + protein inhibitor<BR />
**[[2zhx]] – MtDG + protein inhibitor<BR />
-
**[[1akz]] - hUDG (mutant) <BR />
 
**[[2oxm]], [[2oyt]], [[1q3f]] – hUDG + DNA<BR />
**[[2oxm]], [[2oyt]], [[1q3f]] – hUDG + DNA<BR />
**[[1ssp]], [[2ssp]] - hUDG + DNA+ uracil<BR />
**[[1ssp]], [[2ssp]] - hUDG + DNA+ uracil<BR />
Line 59: Line 78:
**[[3fcf]], [[3fci]], [[3fck]], [[3fcl]], [[2hxm]] – hUDG + inhibitor<BR />
**[[3fcf]], [[3fci]], [[3fck]], [[3fcl]], [[2hxm]] – hUDG + inhibitor<BR />
**[[1ugh]] - hUDG (mutant) + protein inhibitor<BR />
**[[1ugh]] - hUDG (mutant) + protein inhibitor<BR />
-
**[[2jhq]] – UDG – ''Vibrio cholerae''<BR />
 
**[[3cxm]] – UDG residues 129-373 + 5-bromo-uracil<BR />
**[[3cxm]] – UDG residues 129-373 + 5-bromo-uracil<BR />
-
**[[2owq]], [[2owr]] – UDG (mutant) – Vaccinia virus<BR />
 
-
**[[2d3y]], [[1ui0]], [[1ui1]] – TtUDG – ''Thermus thermophilus''<BR />
 
**[[2dp6]], [[2dem]], [[2ddg]] – TtUDG + DNA<BR />
**[[2dp6]], [[2dem]], [[2ddg]] – TtUDG + DNA<BR />
**[[2j8x]] – UDG glycosylase domain + protein inhibitor – Epstein-Barr virus<BR />
**[[2j8x]] – UDG glycosylase domain + protein inhibitor – Epstein-Barr virus<BR />
-
**[[1lqj]] – EcUDG<BR />
 
-
**[[1flz]] - EcUDG (mutant) <BR />
 
**[[2eug]], [[3eug]], [[1eug]], [[4eug]], [[5eug]] - EcUDG (mutant) + uracil<BR />
**[[2eug]], [[3eug]], [[1eug]], [[4eug]], [[5eug]] - EcUDG (mutant) + uracil<BR />
**[[1mwj]], [[1mwi]], [[1mtl]] – EcUDG + DNA<BR />
**[[1mwj]], [[1mwi]], [[1mtl]] – EcUDG + DNA<BR />
**[[1lqg]], [[1lqm]], [[1eui]], [[1uug]] - EcUDG + protein inhibitor<BR />
**[[1lqg]], [[1lqm]], [[1eui]], [[1uug]] - EcUDG + protein inhibitor<BR />
**[[2uug]] - EcUDG (mutant) + protein inhibitor<BR />
**[[2uug]] - EcUDG (mutant) + protein inhibitor<BR />
 +
**[[3uf7]] - EcUDG + single-stranded DNA-binding protein peptide<br />
 +
**[[3ufm]] - DrUDG + single-stranded DNA-binding protein peptide<br />
**[[2c53]], [[2c56]] – HhUDG (mutant) – Human herpesvirus<BR />
**[[2c53]], [[2c56]] – HhUDG (mutant) – Human herpesvirus<BR />
**[[1lau]] – HhUDG + DNA<BR />
**[[1lau]] – HhUDG + DNA<BR />
-
**[[1udh]], [[1udg]] – HsUDG _ Herpes simplex virus<BR />
 
**[[1udi]] - HsUDG + protein inhibitor<BR />
**[[1udi]] - HsUDG + protein inhibitor<BR />
-
**[[2c2p]], [[2boo]] – DrUDG – ''Deinococcus radiodurans''<BR />
+
**[[3wdg]] – SaUDG + protein<br />
-
**[[2c2q]] – DrUDG (mutant) <BR />
+
**[[3zoq]] – BsUDG + p56 <br />
-
**[[1vk2]], [[1l9g]] – TmUDG - ''Thermotoga maritime''<BR />
+
**[[4l5n]] – HsUDG + p56 <br />
-
**[[1okb]] – UDG catalytic domain – Atlantic cod
+
**[[4lyl]] - AcUDG + protein inhibitor<br />
 +
**[[4od8]], [[4oda]] - VvUDG + DNA polymerase processivity factor<br />
*Smug1 Uracil DG
*Smug1 Uracil DG
Line 90: Line 106:
**[[1kea]] – TDG – ''Methanothermobacter thermautotrophicus''<BR />
**[[1kea]] – TDG – ''Methanothermobacter thermautotrophicus''<BR />
**[[1mug]] – EcTDG
**[[1mug]] – EcTDG
 +
 +
*G/T mismatch-specific thymine DG
 +
 +
**[[3uo7]], [[4jgc]] - hTDG + DNA + carboxylcytosine<br />
 +
**[[3uob]] - hTDG + DNA + fluoro-cytidine<br />
 +
**[[4fnc]] - hTDG + DNA + hydroxymethyluracil<br />
*Human 8-oxoguanine DG
*Human 8-oxoguanine DG
Line 115: Line 137:
*Methyladenine DG
*Methyladenine DG
-
**[[3qi5]], [[1ewn]], [[1f4r]], [[1f6o]], [[1bnk]] – hAlkDG + DNA<BR />
 
**[[3bvs]] – BcAlkDG – ''Bacillus cereus''<BR />
**[[3bvs]] – BcAlkDG – ''Bacillus cereus''<BR />
-
**[[3jx7]], [[3jxy]], [[3jxz]], [[3jy1]] - BcAlkDG + DNA<BR />
 
**[[1pvs]], [[1p7m]], [[1mpg]] – EcAlkDG<BR />
**[[1pvs]], [[1p7m]], [[1mpg]] – EcAlkDG<BR />
**[[1nku]], [[1lmz]] – EcAlkDG - NMR<BR />
**[[1nku]], [[1lmz]] – EcAlkDG - NMR<BR />
-
**[[3ogd]], [[3oh6]], [[3oh9]] - EcAlkDG (mutant) + DNA<BR />
 
-
**[[3d4v]], [[3cvs]], [[3cvt]], [[3cw7]], [[3cwa]], [[3cws]], [[3cwt]], [[3cwu]], [[1diz]] - EcAlkDG + DNA<BR />
 
**[[2ofk]] – StAlkDG – ''Salmonella typhi''<BR />
**[[2ofk]] – StAlkDG – ''Salmonella typhi''<BR />
-
**[[2ofi]] – StAlkDG + DNA<BR />
 
**[[2jhj]], [[2jhn]] – AlkDG – ''Archaeoglobus fulgidus''<BR />
**[[2jhj]], [[2jhn]] – AlkDG – ''Archaeoglobus fulgidus''<BR />
**[[2jg6]] – AlkDG – ''Staphylococcus aureus''<BR />
**[[2jg6]] – AlkDG – ''Staphylococcus aureus''<BR />
**[[1pu6]] – HpAlkDG – ''Helicobacter pylori''<BR />
**[[1pu6]] – HpAlkDG – ''Helicobacter pylori''<BR />
-
**[[1pu7]], [[1pu8]] – HpAlkDG + adenine derivative
+
**[[4ai4]] – SaAlkDG (mutant)<br />
 +
 
 +
*Methyladenine DG complex
 +
 
 +
**[[3qi5]], [[1ewn]], [[1f4r]], [[1f6o]], [[1bnk]], [[3uby]] – hAlkDG + DNA<BR />
 +
**[[3jx7]], [[3jxy]], [[3jxz]], [[3jy1]] - BcAlkDG + DNA<BR />
 +
**[[3ogd]], [[3oh6]], [[3oh9]] - EcAlkDG (mutant) + DNA<BR />
 +
**[[3d4v]], [[3cvs]], [[3cvt]], [[3cw7]], [[3cwa]], [[3cws]], [[3cwt]], [[3cwu]], [[1diz]] - EcAlkDG + DNA<BR />
 +
**[[2ofi]] – StAlkDG + DNA<BR />
 +
**[[3s6i]] – AlkDG + DNA – fission yeast<br />
 +
**[[1pu7]], [[1pu8]] – HpAlkDG + adenine derivative<br />
 +
**[[4aia]] – SaAlkDG + methyladenine<br />
 +
**[[4ai5]] – SaAlkDG (mutant) + methyladenine<br />
*Formamidopyrimidine DG
*Formamidopyrimidine DG

Revision as of 10:45, 25 March 2015

Image:1akz.png
Crystal Structure of DNA glycosylate, 1akz

Template:STRUCTURE 3fsp











DNA glycosylase (DG) are enzymes which remove damaged DNA bases by flipping them out of the double helix followed by their cleavage. Monofunctional DG have only glycosylase activity; bifunctional DG also act as lysates; ADG, UDG, TDG remove adenine, uracil, thymine from DNA.

  • Adenine DNA glycosylase is also called MutY.
  • Smug1 is a single-strand selective monofunctional UDG.
  • 8-oxoguanine DNA glycosylase recognize oxidized bases.
  • Human 8-oxoguanine GD is named hOgg1. See details on Ogg1 in 8-Oxoguanine Glycosylase.
  • Methyladenine DNA glycosylase recognize methylated adenine; for details see Alka1.
  • Formamidopyrimidine DG (FPG) or MutM or Fapy-DNA glycosylase removes oxidized purines from damaged DNA. More about FPG in
  • Fpg Nei Protein Family
  • Fpg Nei Protein Superfamily.

3D Structures of DNA glycosylate

Updated on 25-March-2015

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman, Jaime Prilusky

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