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Exonuclease
From Proteopedia
(Difference between revisions)
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**[[4jrp]], [[4jrq]] – EcExN-I + oligonucleotide<br /> | **[[4jrp]], [[4jrq]] – EcExN-I + oligonucleotide<br /> | ||
**[[3qe9]] – hExN-I (mutant) + DNA – human<br /> | **[[3qe9]] – hExN-I (mutant) + DNA – human<br /> | ||
| - | **[[3qea]], [[3qeb]] - hExN-I + DNA | + | **[[3qea]], [[3qeb]] - hExN-I + DNA<br /> |
| + | **[[4rg8]] – ExN-I (mutant) – ''Methylocaldum szegedienes''<br /> | ||
*ExN-III | *ExN-III | ||
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**[[1exn]], [[1xo1]] - T5-5’-ExN (mutant)<br /> | **[[1exn]], [[1xo1]] - T5-5’-ExN (mutant)<br /> | ||
**[[1avq]] – BlExN λ (mutant) – Bacteriophage λ<br /> | **[[1avq]] – BlExN λ (mutant) – Bacteriophage λ<br /> | ||
| - | **[[3slp]] - BlExN λ + DNA<br /> | + | **[[3slp]], [[4wuz]] - BlExN λ + DNA<br /> |
**[[3sm4]] - BlExN λ (mutant) + DNA<br /> | **[[3sm4]] - BlExN λ (mutant) + DNA<br /> | ||
**[[3k93]] – ExN – Haemophilus somnus | **[[3k93]] – ExN – Haemophilus somnus | ||
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**[[2br2]] – SsExN-I + ExN-II – ''Sulfolobus solfataricus''<br /> | **[[2br2]] – SsExN-I + ExN-II – ''Sulfolobus solfataricus''<br /> | ||
**[[2jea]], [[2je6]], [[2jeb]] - SsExN-I (mutant) + ExN-II + RNA-binding protein 1<br /> | **[[2jea]], [[2je6]], [[2jeb]] - SsExN-I (mutant) + ExN-II + RNA-binding protein 1<br /> | ||
| - | **[[2hbj]], [[2hbk]], [[2hbl]], [[2hbm]] – yExN Rrp6 (mutant) <br /> | + | **[[2hbj]], [[2hbk]], [[2hbl]], [[2hbm]] – yExN Rrp6 (mutant) - yeast<br /> |
**[[2ja9]] – yExN Rrp40<br /> | **[[2ja9]] – yExN Rrp40<br /> | ||
**[[2vnu]] – yExN Rrp44 + DNA<br /> | **[[2vnu]] – yExN Rrp44 + DNA<br /> | ||
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**[[2ioc]] - hExN Trex1 N terminal<br /> | **[[2ioc]] - hExN Trex1 N terminal<br /> | ||
**[[2nn6]] – hExN Rrp41, Rrp45, Rrp42, Rrp40, Prp43, Rrp46, Mtr3, Csl4, Rrp4<br /> | **[[2nn6]] – hExN Rrp41, Rrp45, Rrp42, Rrp40, Prp43, Rrp46, Mtr3, Csl4, Rrp4<br /> | ||
| - | **[[4ifd]] - yExN Rrp6, Rrp45, Rrp42, Rrp40, Prp43, Rrp46, Mtr3, Csl4, Rrp4, Rrp6, Ski6, Dis3 + RNA<br /> | + | **[[4wfc]] - yExN Rrp6 + Lrp1<br /> |
| + | **[[4wfd]] - yExN Rrp6 + Lrp1 + Dob1<br /> | ||
| + | **[[4ifd]], [[4oo1]] - yExN Rrp6, Rrp45, Rrp42, Rrp40, Prp43, Rrp46, Mtr3, Csl4, Rrp4, Rrp6, Ski6, Dis3 + RNA<br /> | ||
*Other ExN | *Other ExN | ||
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**[[1zbh]] - hExn Eri1 (mutant) + DNA<br /> | **[[1zbh]] - hExn Eri1 (mutant) + DNA<br /> | ||
**[[1y97]] – hExN Trex2<br /> | **[[1y97]] – hExN Trex2<br /> | ||
| - | **[[3zdk]] – hExN Apollo<br /> | + | **[[3zdk]], [[5aho]] – hExN Apollo<br /> |
**[[2o4g]] - mExN Trex1 + nucleotide – mouse<br /> | **[[2o4g]] - mExN Trex1 + nucleotide – mouse<br /> | ||
**[[3mxj]] - mExN Trex1<br /> | **[[3mxj]] - mExN Trex1<br /> | ||
| Line 94: | Line 97: | ||
**[[3sz4]] - LhExN alkaline + AMP<br /> | **[[3sz4]] - LhExN alkaline + AMP<br /> | ||
**[[3sz5]] - LhExN alkaline + polynucleotide<br /> | **[[3sz5]] - LhExN alkaline + polynucleotide<br /> | ||
| - | **[[3e2v]] – yExN | + | **[[3e2v]] – yExN <br /> |
| + | **[[4lty]], [[4lu9]], [[4m0v]] – EcExN sbcD<br /> | ||
}} | }} | ||
Revision as of 07:24, 1 April 2015
Exonucleases (ExN) cleave nucleotides at the end of a polynucleotide chain. In E. coli there are ExN I to VIII.
- ExN-I cleaves single-stranded DNA.
- ExN-II is associated with DNA polymerase.
- ExN-III cleaves double-stranded DNA.
- ExN-IV cleavage results in nucleoside monophosphate.
- ExN-V cleaves linear double-stranded DNA.
- ExN-VIII requires a free 5’ OH group for reacting.
- ExN were found in human and yeast as well.
3D Structures of exonuclease
Updated on 01-April-2015
