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4odb
From Proteopedia
(Difference between revisions)
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| - | ''' | + | ==Crystal structure of the T1L reovirus attachment protein sigma1 in complex with Junctional Adhesion Molecule-A== |
| - | + | <StructureSection load='4odb' size='340' side='right' caption='[[4odb]], [[Resolution|resolution]] 3.20Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4odb]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ODB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ODB FirstGlance]. <br> | |
| - | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4gu3|4gu3]], [[4gu4|4gu4]], [[3eoy|3eoy]], [[1nbq|1nbq]]</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4odb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4odb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4odb RCSB], [http://www.ebi.ac.uk/pdbsum/4odb PDBsum]</span></td></tr> | |
| - | + | </table> | |
| - | [[ | + | == Function == |
| - | [[ | + | [[http://www.uniprot.org/uniprot/SIGM1_REOVL SIGM1_REOVL]] Fiber-like molecule that attaches the virion to the host cell membrane by binding to the primary receptor F11R/JAM-A and to sialic acid containing proteins (coreceptor). The interaction of sigma-1 with F11R is required for NF-kB activation and apoptosis. Binding to both sialic acid and F11R is required to induce maximal levels of apoptosis (By similarity). [[http://www.uniprot.org/uniprot/JAM1_HUMAN JAM1_HUMAN]] Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3. The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly (By similarity). Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier. Involved in platelet activation. In case of orthoreovirus infection, serves as receptor for the virus. |
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Stehle, T]] | [[Category: Stehle, T]] | ||
| + | [[Category: Stettner, E]] | ||
| + | [[Category: Beta spiral]] | ||
| + | [[Category: Capsid protein]] | ||
| + | [[Category: Cell adhesion molecule]] | ||
| + | [[Category: Greek key motif]] | ||
| + | [[Category: Immunoglobulin fold]] | ||
| + | [[Category: Viral attachment protein]] | ||
| + | [[Category: Viral protein]] | ||
| + | [[Category: Viral receptor]] | ||
Revision as of 13:18, 1 April 2015
Crystal structure of the T1L reovirus attachment protein sigma1 in complex with Junctional Adhesion Molecule-A
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