This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
4yru
From Proteopedia
(Difference between revisions)
m (Protected "4yru" [edit=sysop:move=sysop]) |
|||
| Line 1: | Line 1: | ||
| - | ''' | + | ==Crystal structure of C-terminally truncated Neuronal Calcium Sensor (NCS-1) from Rattus norvegicus== |
| - | + | <StructureSection load='4yru' size='340' side='right' caption='[[4yru]], [[Resolution|resolution]] 2.80Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4yru]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YRU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YRU FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4yru FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yru OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4yru RCSB], [http://www.ebi.ac.uk/pdbsum/4yru PDBsum]</span></td></tr> | |
| - | + | </table> | |
| - | [[Category: | + | == Function == |
| + | [[http://www.uniprot.org/uniprot/NCS1_RAT NCS1_RAT]] Neuronal calcium sensor, regulator of G protein-coupled receptor phosphorylation in a calcium dependent manner. Directly regulates GRK1 (RHOK), but not GRK2 to GRK5. Can substitute for calmodulin. Stimulates PI4KB kinase activity. Involved in long-term synaptic plasticity through its interaction with PICK1. May also play a role in neuron differentiation through inhibition of the activity of N-type voltage-gated calcium channel.<ref>PMID:17502602</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Derrick, J P]] | ||
[[Category: Karrupiah, V]] | [[Category: Karrupiah, V]] | ||
| - | + | [[Category: Lian, L Y]] | |
| - | [[Category: Lian, L | + | |
[[Category: Mayans, O]] | [[Category: Mayans, O]] | ||
| - | [[Category: | + | [[Category: Pandalaneni, S]] |
| + | [[Category: C-terminal truncation]] | ||
| + | [[Category: Calcium sensor]] | ||
| + | [[Category: Ef-hand]] | ||
| + | [[Category: Signaling protein]] | ||
Revision as of 13:23, 1 April 2015
Crystal structure of C-terminally truncated Neuronal Calcium Sensor (NCS-1) from Rattus norvegicus
| |||||||||||
