Farnesyltransferase
From Proteopedia
(Difference between revisions)
| Line 51: | Line 51: | ||
**[[1sa5]], [[3e30]], [[3e32]], [[3e33]], [[3e34]], [[3e37]] - rFTase + inhibitor + FPP<BR /> | **[[1sa5]], [[3e30]], [[3e32]], [[3e33]], [[3e34]], [[3e37]] - rFTase + inhibitor + FPP<BR /> | ||
| + | **[[4gtm]], [[4gto]], [[4gtp]], [[4gtq]], [[4gtr]] - rFTase α subunit + β subunit + inhibitor + FPP<br /> | ||
**[[2zir]], [[2zis]] - rFTase α subunit (mutant) + β subunit + inhibitor + FPP<BR /> | **[[2zir]], [[2zis]] - rFTase α subunit (mutant) + β subunit + inhibitor + FPP<BR /> | ||
**[[1jcq]] – hFTase α subunit (mutant) + β subunit + inhibitor + FPP– human<br /> | **[[1jcq]] – hFTase α subunit (mutant) + β subunit + inhibitor + FPP– human<br /> | ||
| Line 58: | Line 59: | ||
**[[3q7a]], [[3q7f]] - CnFTase + inhibitor + FPP<BR /> | **[[3q7a]], [[3q7f]] - CnFTase + inhibitor + FPP<BR /> | ||
**[[3fsx]], [[3sfy]] - CnFTase + inhibitor + FPP-analog<br /> | **[[3fsx]], [[3sfy]] - CnFTase + inhibitor + FPP-analog<br /> | ||
| + | **[[3sfx]] - CnFTase α subunit + β subunit + inhibitor + FPP<br /> | ||
**[[4lnb]], [[4lng]], [[4mbg]] - AfFTase (mutant) + inhibitor + FPP<br /> | **[[4lnb]], [[4lng]], [[4mbg]] - AfFTase (mutant) + inhibitor + FPP<br /> | ||
Revision as of 06:52, 2 April 2015
Farnesyltransferase (FTase) is part of the prenyltransferase group. FTase modifies proteins by adding farnesyl diphosphate (FPP) – an isoprenoid lipid – to a cysteine near the C terminal. This addition forms a thioether linkage, makes the protein more hydrophobic and associates it with the membrane. Farnesylated proteins – like those of the Ras family - are involved in cellular signaling. Thus, FTase inhibitors are being tested as anti-cancer agents. FTase are composed of 2 subunits. The β subunit coordinates a Zn atom.
3D structures of farnesyltransferase
Updated on 02-April-2015
