Fibroblast growth factor receptor
From Proteopedia
(Difference between revisions)
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**[[1fgk]], [[3kxx]], [[3ky2]] – hFGFR1 TKD (mutant) - human <br /> | **[[1fgk]], [[3kxx]], [[3ky2]] – hFGFR1 TKD (mutant) - human <br /> | ||
| - | **[[1agw]], [[1fgi]], [[2fgi]], [[3c4f]], [[3js2]], [[3rhx]], [[4f63]], [[4f64]], [[4f65]], [[3tt0]], [[4nk9]], [[4nka]], [[4nks]] – hFGFR1 TKD (mutant) + inhibitor <br /> | + | **[[4uwy]] – hFGFR1 TKD <br /> |
| + | **[[4wun]], [[5am6]] – hFGFR1 TKD + inhibitor <br /> | ||
| + | **[[1agw]], [[1fgi]], [[2fgi]], [[3c4f]], [[3js2]], [[3rhx]], [[4f63]], [[4f64]], [[4f65]], [[3tt0]], [[4nk9]], [[4nka]], [[4nks]], [[3wj6]], [[5am7]] – hFGFR1 TKD (mutant) + inhibitor <br /> | ||
**[[3krj]] – hFGFR1 TKD residues 538-678, 753-922 (mutant) + inhibitor <br /> | **[[3krj]] – hFGFR1 TKD residues 538-678, 753-922 (mutant) + inhibitor <br /> | ||
**[[1xr0]] – hFGFR1 residues 409-430 + FGFR signaling adaptor N terminal - NMR<br /> | **[[1xr0]] – hFGFR1 residues 409-430 + FGFR signaling adaptor N terminal - NMR<br /> | ||
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**[[1ry7]] – hFGFR3 LBD + hFGF1<br /> | **[[1ry7]] – hFGFR3 LBD + hFGF1<br /> | ||
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| + | *FGFR4 | ||
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| + | *''FGFR4 tyrosine kinase domain'' | ||
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| + | **[[4tye]], [[4tyg]], [[4tyi]], [[4tyj]] – hFGFR4 TKD <br /> | ||
| + | **[[4qqj]] – hFGFR4 TKD (mutant) <br /> | ||
| + | **[[4qrc]], [[4r6v]], [[4qqc]], [[4qq5]], [[4uxq]], [[4xcu]] – hFGFR4 TKD (mutant) + irreversible inhibitor<br /> | ||
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}} | }} | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 06:35, 5 April 2015
Fibroblast growth factor receptors (FGFR) are receptors which bind fibroblast growth factors (FGF). FGFR consist of an extracellular ligand-binding domain (LBD), transmembrane helix domain and cytoplasmic tyrosine kinase activity domain (TKD) with phosphorylated tyrosine designated PTR. FGFR LBD contains 3 immunoglobulin-like domains D1, D2 and D3. Each FGFR can activate several FGFs. Five FGFRs have been identified so far. FGFRs differ in their ligand specificity and tissue distribution. The binding of FGF to FGFR starts a cascade of signaling which influences mitogenesis and differentiation.
3D structures of fibroblast growth factor receptor
Updated on 05-April-2015
