2srt
From Proteopedia
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| - | [[Image:2srt.gif|left|200px]]< | + | [[Image:2srt.gif|left|200px]] |
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| - | '''CATALYTIC DOMAIN OF HUMAN STROMELYSIN-1 AT PH 5.5 AND 40OC COMPLEXED WITH INHIBITOR''' | + | {{Structure |
| + | |PDB= 2srt |SIZE=350|CAPTION= <scene name='initialview01'>2srt</scene> | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene> and <scene name='pdbligand=INH:N-(R-CARBOXY-ETHYL)-ALPHA-(S)-(2-PHENYLETHYL)GLYCYL-L-ARGININE-N-PHENYLAMIDE'>INH</scene> | ||
| + | |ACTIVITY= [http://en.wikipedia.org/wiki/Stromelysin_1 Stromelysin 1], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.17 3.4.24.17] | ||
| + | |GENE= HUMAN STROMELYSIN-1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | ||
| + | }} | ||
| + | |||
| + | '''CATALYTIC DOMAIN OF HUMAN STROMELYSIN-1 AT PH 5.5 AND 40OC COMPLEXED WITH INHIBITOR''' | ||
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==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2SRT is a [ | + | 2SRT is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry 1SRT. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2SRT OCA]. |
==Reference== | ==Reference== | ||
| - | The NMR structure of the inhibited catalytic domain of human stromelysin-1., Gooley PR, O'Connell JF, Marcy AI, Cuca GC, Salowe SP, Bush BL, Hermes JD, Esser CK, Hagmann WK, Springer JP, et al., Nat Struct Biol. 1994 Feb;1(2):111-8. PMID:[http:// | + | The NMR structure of the inhibited catalytic domain of human stromelysin-1., Gooley PR, O'Connell JF, Marcy AI, Cuca GC, Salowe SP, Bush BL, Hermes JD, Esser CK, Hagmann WK, Springer JP, et al., Nat Struct Biol. 1994 Feb;1(2):111-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7656014 7656014] |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: metzincin]] | [[Category: metzincin]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:38:45 2008'' |
Revision as of 16:38, 20 March 2008
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| Ligands: | and | ||||||
| Gene: | HUMAN STROMELYSIN-1 (Homo sapiens) | ||||||
| Activity: | Stromelysin 1, with EC number 3.4.24.17 | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
CATALYTIC DOMAIN OF HUMAN STROMELYSIN-1 AT PH 5.5 AND 40OC COMPLEXED WITH INHIBITOR
Contents |
Overview
The three-dimensional structure of the catalytic domain of stromelysin-1 complexed with an N-carboxyl alkyl inhibitor has been determined by NMR methods. The global fold consists of three helices, a five stranded beta-sheet and a methionine located in a turn near the catalytic histidines, classifying stromelysin-1 as a metzincin. Stromelysin-1 is unique in having two independent zinc binding sites: a catalytic site and a structural site. The inhibitor binds in an extended conformation. The S1' subsite is a deep hydrophobic pocket, whereas S2' appears shallow and S3' open.
Disease
Known diseases associated with this structure: Coronary heart disease, susceptibility to OMIM:[185250]
About this Structure
2SRT is a Single protein structure of sequence from Homo sapiens. This structure supersedes the now removed PDB entry 1SRT. Full crystallographic information is available from OCA.
Reference
The NMR structure of the inhibited catalytic domain of human stromelysin-1., Gooley PR, O'Connell JF, Marcy AI, Cuca GC, Salowe SP, Bush BL, Hermes JD, Esser CK, Hagmann WK, Springer JP, et al., Nat Struct Biol. 1994 Feb;1(2):111-8. PMID:7656014
Page seeded by OCA on Thu Mar 20 18:38:45 2008
Categories: Homo sapiens | Single protein | Stromelysin 1 | Connell, J F.O. | Gooley, P R. | INH | ZN | Metzincin
