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4xxc

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'''Unreleased structure'''
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==HLA-B*1801 in complex with a self-peptide, DELEIKAY==
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<StructureSection load='4xxc' size='340' side='right' caption='[[4xxc]], [[Resolution|resolution]] 1.43&Aring;' scene=''>
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The entry 4xxc is ON HOLD until Jan 30 2017
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4xxc]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XXC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XXC FirstGlance]. <br>
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Authors: Hibbert, K.M., Rossjohn, J., Gras, S.
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4jqv|4jqv]]</td></tr>
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Description:
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xxc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xxc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4xxc RCSB], [http://www.ebi.ac.uk/pdbsum/4xxc PDBsum]</span></td></tr>
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[[Category: Unreleased Structures]]
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</table>
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[[Category: Hibbert, K.M]]
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== Disease ==
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[[Category: Rossjohn, J]]
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[[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[http://omim.org/entry/241600 241600]]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref> Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref> <ref>PMID:1336137</ref> <ref>PMID:7554280</ref> <ref>PMID:4586824</ref> <ref>PMID:8084451</ref> <ref>PMID:12119416</ref> <ref>PMID:12796775</ref> <ref>PMID:16901902</ref> <ref>PMID:16491088</ref> <ref>PMID:17646174</ref> <ref>PMID:18835253</ref> <ref>PMID:18395224</ref> <ref>PMID:19284997</ref>
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== Function ==
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[[http://www.uniprot.org/uniprot/1B18_HUMAN 1B18_HUMAN]] Involved in the presentation of foreign antigens to the immune system. [[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Gras, S]]
[[Category: Gras, S]]
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[[Category: Hibbert, K M]]
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[[Category: Rossjohn, J]]
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[[Category: Cross-reactivity]]
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[[Category: Ebv]]
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[[Category: Hla]]
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[[Category: Immune system]]
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[[Category: Tcr]]

Revision as of 11:18, 8 April 2015

HLA-B*1801 in complex with a self-peptide, DELEIKAY

4xxc, resolution 1.43Å

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