2uva

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[[Image:2uva.gif|left|200px]]<br /><applet load="2uva" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:2uva.gif|left|200px]]
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caption="2uva, resolution 3.1&Aring;" />
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'''CRYSTAL STRUCTURE OF FATTY ACID SYNTHASE FROM THERMOMYCES LANUGINOSUS AT 3.1 ANGSTROM RESOLUTION. THIS FILE CONTAINS THE BETA SUBUNITS OF THE FATTY ACID SYNTHASE. THE ENTIRE CRYSTAL STRUCTURE CONSISTS OF ONE HETERODODECAMERIC FATTY ACID SYNTHASE AND IS DESCRIBED IN REMARK 400'''<br />
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{{Structure
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|PDB= 2uva |SIZE=350|CAPTION= <scene name='initialview01'>2uva</scene>, resolution 3.1&Aring;
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|SITE= <scene name='pdbsite=AC1:Fmn+Binding+Site+For+Chain+G'>AC1</scene>, <scene name='pdbsite=AC2:Fmn+Binding+Site+For+Chain+H'>AC2</scene>, <scene name='pdbsite=AC3:Fmn+Binding+Site+For+Chain+I'>AC3</scene>, <scene name='pdbsite=AC4:Fmn+Binding+Site+For+Chain+J'>AC4</scene>, <scene name='pdbsite=AC5:Fmn+Binding+Site+For+Chain+K'>AC5</scene> and <scene name='pdbsite=AC6:Fmn+Binding+Site+For+Chain+L'>AC6</scene>
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|LIGAND= <scene name='pdbligand=FMN:FLAVIN MONONUCLEOTIDE'>FMN</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''CRYSTAL STRUCTURE OF FATTY ACID SYNTHASE FROM THERMOMYCES LANUGINOSUS AT 3.1 ANGSTROM RESOLUTION. THIS FILE CONTAINS THE BETA SUBUNITS OF THE FATTY ACID SYNTHASE. THE ENTIRE CRYSTAL STRUCTURE CONSISTS OF ONE HETERODODECAMERIC FATTY ACID SYNTHASE AND IS DESCRIBED IN REMARK 400'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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2UVA is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Thermomyces_lanuginosus Thermomyces lanuginosus] with <scene name='pdbligand=FMN:'>FMN</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Known structural/functional Sites: <scene name='pdbsite=AC1:Fmn+Binding+Site+For+Chain+G'>AC1</scene>, <scene name='pdbsite=AC2:Fmn+Binding+Site+For+Chain+H'>AC2</scene>, <scene name='pdbsite=AC3:Fmn+Binding+Site+For+Chain+I'>AC3</scene>, <scene name='pdbsite=AC4:Fmn+Binding+Site+For+Chain+J'>AC4</scene>, <scene name='pdbsite=AC5:Fmn+Binding+Site+For+Chain+K'>AC5</scene> and <scene name='pdbsite=AC6:Fmn+Binding+Site+For+Chain+L'>AC6</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UVA OCA].
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2UVA is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Thermomyces_lanuginosus Thermomyces lanuginosus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UVA OCA].
==Reference==
==Reference==
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Structure of fungal fatty acid synthase and implications for iterative substrate shuttling., Jenni S, Leibundgut M, Boehringer D, Frick C, Mikolasek B, Ban N, Science. 2007 Apr 13;316(5822):254-61. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17431175 17431175]
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Structure of fungal fatty acid synthase and implications for iterative substrate shuttling., Jenni S, Leibundgut M, Boehringer D, Frick C, Mikolasek B, Ban N, Science. 2007 Apr 13;316(5822):254-61. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17431175 17431175]
[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Thermomyces lanuginosus]]
[[Category: Thermomyces lanuginosus]]
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[[Category: transferase]]
[[Category: transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:50:52 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:40:11 2008''

Revision as of 16:40, 20 March 2008

Image:2uva.gif


PDB ID 2uva

Drag the structure with the mouse to rotate
, resolution 3.1Å
Sites: , , , , and
Ligands:
Coordinates: save as pdb, mmCIF, xml



CRYSTAL STRUCTURE OF FATTY ACID SYNTHASE FROM THERMOMYCES LANUGINOSUS AT 3.1 ANGSTROM RESOLUTION. THIS FILE CONTAINS THE BETA SUBUNITS OF THE FATTY ACID SYNTHASE. THE ENTIRE CRYSTAL STRUCTURE CONSISTS OF ONE HETERODODECAMERIC FATTY ACID SYNTHASE AND IS DESCRIBED IN REMARK 400


Overview

We report crystal structures of the 2.6-megadalton alpha6beta6 heterododecameric fatty acid synthase from Thermomyces lanuginosus at 3.1 angstrom resolution. The alpha and beta polypeptide chains form the six catalytic domains required for fatty acid synthesis and numerous expansion segments responsible for extensive intersubunit connections. Detailed views of all active sites provide insights into substrate specificities and catalytic mechanisms and reveal their unique characteristics, which are due to the integration into the multienzyme. The mode of acyl carrier protein attachment in the reaction chamber, together with the spatial distribution of active sites, suggests that iterative substrate shuttling is achieved by a relatively restricted circular motion of the carrier domain in the multifunctional enzyme.

About this Structure

2UVA is a Single protein structure of sequence from Thermomyces lanuginosus. Full crystallographic information is available from OCA.

Reference

Structure of fungal fatty acid synthase and implications for iterative substrate shuttling., Jenni S, Leibundgut M, Boehringer D, Frick C, Mikolasek B, Ban N, Science. 2007 Apr 13;316(5822):254-61. PMID:17431175

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